GATA-3 as a Potential Therapeutic Target for Insulin Resistance and Type 2 Diabetes Mellitus

被引：16
作者：
Al-Jaber, Hend [1 ]
Al-Mansoori, Layla [1 ]
Elrayess, Mohamed A. [1 ]
机构：
[1] Qatar Univ, Biomed Res Ctr, Doha, Qatar
来源：
CURRENT DIABETES REVIEWS | 2021年 / 17卷 / 02期
关键词：
GATA-3; therapeutic target; insulin resistance; adipogenesis; inflammation; type; 2; diabetes; TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE INFLAMMATION; HUMAN SUBCUTANEOUS ADIPOGENESIS; REGULATORY T-CELLS; TRANSCRIPTION FACTORS; METABOLICALLY HEALTHY; FACTOR-ALPHA; INHIBITS ADIPOGENESIS; IMPAIRED ADIPOGENESIS; LINKING OBESITY;
D O I：
10.2174/1573399816666200705210417
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. The anti-adipogenic transcription factor GATA-3 was identified as one of the potential molecular targets responsible for the impairment of adipogenesis. The expression of GATA-3 is higher in insulinresistant obese individuals compared to BMI-matched insulin-sensitive counterparts. Adipose tissue inflammation is a crucial mediator of this process. Hyperglycemia mediates the activation of the immune system, partially through upregulation of GATA-3, causing exacerbation of the inflammatory state associated with obesity. This review discusses the evidence supporting the inhibition of GATA-3 as a useful therapeutic strategy in obesity-associated insulin resistance and type 2 diabetes, through up-regulation adipogenesis and amelioration of the immune response.
引用
收藏
页码：169 / 179
页数：11
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