GATA-3 as a Potential Therapeutic Target for Insulin Resistance and Type 2 Diabetes Mellitus

被引：13
作者：
Al-Jaber, Hend [1 ]
Al-Mansoori, Layla [1 ]
Elrayess, Mohamed A. [1 ]
机构：
[1] Qatar Univ, Biomed Res Ctr, Doha, Qatar
来源：
CURRENT DIABETES REVIEWS | 2021年 / 17卷 / 02期
关键词：
GATA-3; therapeutic target; insulin resistance; adipogenesis; inflammation; type; 2; diabetes; TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE INFLAMMATION; HUMAN SUBCUTANEOUS ADIPOGENESIS; REGULATORY T-CELLS; TRANSCRIPTION FACTORS; METABOLICALLY HEALTHY; FACTOR-ALPHA; INHIBITS ADIPOGENESIS; IMPAIRED ADIPOGENESIS; LINKING OBESITY;
D O I：
10.2174/1573399816666200705210417
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. The anti-adipogenic transcription factor GATA-3 was identified as one of the potential molecular targets responsible for the impairment of adipogenesis. The expression of GATA-3 is higher in insulinresistant obese individuals compared to BMI-matched insulin-sensitive counterparts. Adipose tissue inflammation is a crucial mediator of this process. Hyperglycemia mediates the activation of the immune system, partially through upregulation of GATA-3, causing exacerbation of the inflammatory state associated with obesity. This review discusses the evidence supporting the inhibition of GATA-3 as a useful therapeutic strategy in obesity-associated insulin resistance and type 2 diabetes, through up-regulation adipogenesis and amelioration of the immune response.
引用
收藏
页码：169 / 179
页数：11
相关论文
共 142 条
  • [1] Al-Sulaiti H, 2019, INTECHOPEN, P1
  • [2] Metabolic signature of obesity-associated insulin resistance and type 2 diabetes
    Al-Sulaiti, Haya
    Diboun, Ilhame
    Agha, Maha V.
    Mohamed, Fatima F. S.
    Atkin, Stephen
    Domling, Alex S.
    Elrayess, Mohamed A.
    Mazloum, Nayef A.
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 17 (01)
  • [3] Triglyceride profiling in adipose tissues from obese insulin sensitive, insulin resistant and type 2 diabetes mellitus individuals
    Al-Sulaiti, Haya
    Diboun, Ilhame
    Banu, Sameem
    Al-Emadi, Mohamed
    Amani, Parvaneh
    Harvey, Thomas M.
    Domling, Alex S.
    Latiff, Aishah
    Elrayess, Mohamed A.
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2018, 16
  • [4] Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance
    Almuraikhy, Shamma
    Kafienah, Wael
    Bashah, Moataz
    Diboun, Ilhame
    Jaganjac, Morana
    Al-Khelaifi, Fatima
    Abdesselem, Houari
    Mazloum, Nayef A.
    Alsayrafi, Mohammed
    Mohamed-Ali, Vidya
    Elrayess, Mohamed A.
    [J]. DIABETOLOGIA, 2016, 59 (11) : 2406 - 2416
  • [5] Effects of leptin on the differentiation and metabolism of human adipocytes
    Aprath-Husmann, I
    Röhrig, K
    Gottschling-Zeller, H
    Skurk, T
    Scriba, D
    Birgel, M
    Hauner, H
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2001, 25 (10) : 1465 - 1470
  • [6] INHIBITION OF ADIPOGENESIS BY THE STRESS-INDUCED PROTEIN CHOP (GADD153)
    BATCHVAROVA, N
    WANG, XZ
    RON, D
    [J]. EMBO JOURNAL, 1995, 14 (19) : 4654 - 4661
  • [7] Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein β, implicated in adipocyte differentiation
    Bezy, O
    Elabd, C
    Cochet, O
    Petersen, RK
    Kristiansen, K
    Dani, C
    Ailhaud, R
    Amri, EZ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (12) : 11432 - 11438
  • [8] Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents
    Bjorndal, Bodil
    Burri, Lena
    Staalesen, Vidar
    Skorve, Jon
    Berge, Androlf K.
    [J]. JOURNAL OF OBESITY, 2011, 2011
  • [9] Physical and functional interaction between GATA-3 and Smad3 allows TGF-β regulation of GATA target genes
    Blokzijl, A
    ten Dijke, P
    Ibáñez, CF
    [J]. CURRENT BIOLOGY, 2002, 12 (01) : 35 - 45
  • [10] Regulatory T cells in nonlymphoid tissues
    Burzyn, Dalia
    Benoist, Christophe
    Mathis, Diane
    [J]. NATURE IMMUNOLOGY, 2013, 14 (10) : 1007 - 1013
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