Molecular and cellular biology of rhabdomyosarcoma

被引：77
作者：
De Giovanni, Carla [1 ]
Landuzzi, Lorena [2 ]
Nicoletti, Giordano [2 ]
Lollini, Pier-Luigi [3 ]
Nanni, Patrizia [1 ]
机构：
[1] Univ Bologna, Dept Expt Pathol, Canc Res Sect, I-40126 Bologna, Italy
[2] Rizzoli Orthopaed Inst, Expt Oncol Lab, Bologna, Italy
[3] Dept Hematol & Oncol Sci L eA Seragnoli, I-40126 Bologna, Italy
来源：
FUTURE ONCOLOGY | 2009年 / 5卷 / 09期
关键词：
animal models; gene-expression profiling; IGF; p53; PAX-FKHR; rhabdomyosarcoma; targeted therapy; CHILDRENS-ONCOLOGY-GROUP; PRECLINICAL TESTING PROGRAM; FACTOR-I RECEPTOR; ENDOTHELIAL GROWTH-FACTOR; COMPARATIVE GENOMIC HYBRIDIZATION; HUMAN ALVEOLAR RHABDOMYOSARCOMA; PAX3-FKHR FUSION ONCOPROTEIN; GENE-EXPRESSION SIGNATURE; FACTOR SCATTER FACTOR; MURINE SARCOMA-VIRUS;
D O I：
10.2217/fon.09.97
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Rhabdomyosarcoma is a group of soft-tissue sarcomas that share features of skeletal myogenesis, but show extensive heterogeneity in histology, age and site of onset, and prognosis, This review matches recent molecular data with biological features of rhabdomyosarcoma. Alterations in molecular pathways, animal models, cell of origin and potential new therapeutic targets are discussed.
引用
收藏
页码：1449 / 1475
页数：27
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