α-Iminol Rearrangement Triggered by Pd-Catalyzed C-H Addition to Nitriles Sequences: Synthesis of Functionalized α-Amino Cyclopentanones

被引：12

作者：

Cheng, Na ^{[1
]}

Cui, Shu-Qiang ^{[1
]}

Ma, Qian-Qian ^{[1
]}

Wei, Zhong-Lin ^{[1
]}

Liao, Wei-Wei ^{[1
,2
]}

机构：

[1] Jilin Univ, Coll Chem, Dept Organ Chem, Changchun 130012, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 03期

关键词：

D O I：

10.1021/acs.orglett.0c04214

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A alpha-iminol rearrangement triggered by Pd-catalyzed C-H addition of electronic-rich heteroarenes to cyclobutanone-derived O-acyl cyanohydrins was described, which provided a practical and efficient protocol for the preparation of functionalized alpha-amino cyclopentanones in an atom- and step-economic fashion. In addition, further synthetic transformations of products have also been demonstrated.

引用

页码：1021 / 1025

页数：5

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