Drug delivery to retinal photoreceptors

被引：52

作者：

Himawan, Erico ^{[1
]}

Ekstrom, Per ^{[2
]}

Buzgo, Matej ^{[1
]}

Gaillard, Pieter ^{[3
]}

Stefansson, Einar ^{[4
]}

Marigo, Valeria ^{[5
]}

Loftsson, Thorsteinn ^{[6
]}

Paquet-Durand, Francois ^{[7
]}

机构：

[1] InoCure Sro, Prague, Czech Republic

[2] Lund Univ, Dept Clin Sci Lund, Fac Med, Ophthalmol, Lund, Sweden

[3] 2 BBB Med BV, Leiden, Netherlands

[4] Univ Iceland, Fac Med, Reykjavik, Iceland

[5] Univ Modena & Reggio Emilia, Dept Life Sci, Modena, Italy

[6] Univ Iceland, Fac Pharmaceut Sci, Reykjavik, Iceland

[7] Univ Tubingen, Inst Ophthalm Res, Tubingen, Germany

来源：

DRUG DISCOVERY TODAY | 2019年 / 24卷 / 08期

关键词：

POSTERIOR SEGMENT; NANOPARTICLES; EYE; THERAPY; ANGIOGENESIS; INJECTION; MOVEMENT; EFFICACY; IMPROVES; PRIMATE;

D O I：

10.1016/j.drudis.2019.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood-retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.

引用

页码：1637 / 1643

页数：7

共 48 条

[1] Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles
Apaolaza, P. S.
del Pozo-Rodriguez, A.
Solinis, M. A.
Rodriguez, J. M.
Friedrich, U.
Torrecilla, J.
Weber, B. H. F.
Rodriguez-Gascon, A.
[J]. BIOMATERIALS, 2016, 90 : 40 - 49
[2] Effective delivery of recombinant proteins to rod photoreceptors via lipid nanovesicles
Asteriti, Sabrina
Dal Cortivo, Giuditta
Pontelli, Valeria
Cangiano, Lorenzo
Buffelli, Mario
Dell'Orco, Daniele
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 461 (04) : 665 - 670
[3] Bhatia S., 2016, NATURAL POLYM DRUG D, P33, DOI [doi:10.1007/978-3-319-41129-3_2, DOI 10.1007/978-3-319-41129-32]
[4] Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) as Compared with Generic Caelyx,®/Doxil®A Cerebral Open Flow Microperfusion Pilot Study
Birngruber, Thomas
Raml, Reingard
Gladdines, Werner
Gatschelhofer, Christina
Gander, Edgar
Ghosh, Arijit
Kroath, Thomas
Gaillard, Pieter J.
Pieber, Thomas R.
Sinner, Frank
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 103 (07) : 1945 - 1948
[5] Liposomes for intravitreal drug delivery: A state of the art
Bochot, Amelie
Fattal, Elias
[J]. JOURNAL OF CONTROLLED RELEASE, 2012, 161 (02) : 628 - 634
[6] Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension
Campbell, Matthew
Cassidy, Paul S.
O'Callaghan, Jeffrey
Crosbie, Darragh E.
Humphries, Pete
[J]. PROGRESS IN RETINAL AND EYE RESEARCH, 2018, 62 : 120 - 133
[7] Campbell Matthew, 2013, Methods Mol Biol, V935, P371, DOI 10.1007/978-1-62703-080-9_26
[8] Systemic low-molecular weight drug delivery to pre-selected neuronal regions
Campbell, Matthew
Humphries, Marian M.
Kiang, Anna-Sophia
Nguyen, Anh T. H.
Gobbo, Oliviero L.
Tam, Lawrence C. S.
Suzuki, Mayu
Hanrahan, Finnian
Ozaki, Ema
Farrar, G. -Jane
Kenna, Paul F.
Humphries, Peter
[J]. EMBO MOLECULAR MEDICINE, 2011, 3 (04) : 235 - 245
[9] Systemic delivery of therapeutics to neuronal tissues: a barrier modulation approach
Campbell, Matthew
Ozaki, Ema
Humphries, Peter
[J]. EXPERT OPINION ON DRUG DELIVERY, 2010, 7 (07) : 859 - 869
[10] The Economic Impact of Blindness in Europe
Chakravarthy, Usha
Biundo, Eliana
Saka, Rasit Omer
Fasser, Christina
Bourne, Rupert
Little, Julie-Anne
[J]. OPHTHALMIC EPIDEMIOLOGY, 2017, 24 (04) : 239 - 247

← 1 2 3 4 5 →