The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics

被引：240
作者：
Brooks, Tracy A.
Hurley, Laurence H. [1 ]
机构：
[1] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA
来源：
NATURE REVIEWS CANCER | 2009年 / 9卷 / 12期
基金：
美国国家卫生研究院;
关键词：
NUCLEASE HYPERSENSITIVE ELEMENT; I-MOTIF STRUCTURES; G-QUADRUPLEX DNA; ONCOGENE C-MYC; SINGLE-STRANDED-DNA; HUMAN KRAS PROMOTER; B-CELL LYMPHOMA; GENE-EXPRESSION; HUMAN GENOME; BINDING-PROTEIN;
D O I：
10.1038/nrc2733
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MYC is deregulated in most tumour types, but an effective means to selectively target its aberrant expression is not yet available. Supercoiling that is induced by transcription has been demonstrated to have dynamic effects on DNA in the MYC promoter element: it converts duplex DNA to non-duplex DNA structures, even at considerable distances from the transcriptional start site. These non-duplex DNA structures, which control both turning on and off of transcription and the rate of transcription firing, are amenable to small-molecule targeting. This dynamic system provides a unique opportunity for the treatment of tumours in which MYC is an important oncogene.
引用
收藏
页码：849 / 861
页数：13
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