A Facile Synthesis of N-Aryl Substituted Piperidones

被引：2
作者：
Geng Qian [1 ]
Zhang Hui [1 ]
Cao Weiguo [1 ,2 ,3 ]
Chen Yali [1 ]
机构：
[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2009年 / 27卷 / 10期
基金：
中国国家自然科学基金;
关键词：
N-aryl; 4-piperidone; Ullmann amination; ligand; copper(I) iodide; ONE-POT SYNTHESIS; COUPLING REACTIONS; BOND FORMATION; CONVENIENT SYNTHESIS; ASYMMETRIC-SYNTHESIS; AMINO-ACID; ARYLATION; ULLMANN; IODIDES; HETEROCYCLES;
D O I：
10.1002/cjoc.200990335
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general and efficient procedure for the synthesis of N-aryl-substituted 4-piperidones was developed. The two step syntheses proceeded with an overall yield of 60%-83% using L-proline as the ligand for the Cu(I)-catalyzed Ullmann amination followed by subsequent hydrolysis of resulting ketals.
引用
收藏
页码：1995 / 2000
页数：6
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