Cytochromes P460 and c′-beta;: A new family of high-spin cytochromes c

被引:50
作者
Elmore, Bradley O.
Bergmann, David J.
Klotz, Martin G.
Hooper, Alan B.
机构
[1] Univ Minnesota, Dept Biochem Mol Biol & Biophys, St Paul, MN 55108 USA
[2] Black Hills State Univ, Dept Biol, Spearfish, SD 57799 USA
[3] Univ Louisville, Dept Biol, Louisville, KY 40292 USA
[4] Univ Louisville, Dept Microbiol & Immunol, Louisville, KY 40292 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
cytochrome c '; cytochrome P460; denitrification; N-oxide detoxification; bacterial enzyme evolution;
D O I
10.1016/j.febslet.2007.01.068
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cytochromes-P460 of Nitrosomonas europaea and Methylococcus capsulatus (Bath), and the cytochrome c' of M. capsulatus, believed to be involved in binding or transformation of N-oxides, are shown to represent an evolutionarily related new family of monoheme, similar to 17 kDa, cytochromes e found in the genomes of diverse Protcobacteria. All members of this family have a predicted secondary structure predominantly of beta-sheets in contrast to the predominantly alpha-helical cytochromes c' found in photoheterotrophic and denitrifying Proteobacteria. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:911 / 916
页数:6
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