Irreversible Electroporation Enhanced by Radiofrequency Ablation: An In Vitro and Computational Study in a 3D Liver Tumor Model

被引:15
作者
Fang, Zheng [1 ]
Mao, Huimin [2 ]
Moser, Michael A. J. [3 ]
Zhang, Wenjun [4 ]
Qian, Zhiqin [2 ]
Zhang, Bing [1 ]
机构
[1] Shanghai Univ, Sch Mechatron Engn & Automat, Energy Based Tumor Ablat Lab, 99 Shangda Rd, Shanghai 200444, Peoples R China
[2] East China Univ Sci & Technol, Sch Mech & Power Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China
[3] Univ Saskatchewan, Dept Surg, Saskatoon, SK, Canada
[4] Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK, Canada
基金
中国国家自然科学基金;
关键词
Irreversible electroporation; Radiofrequency ablation; Tumor ablation enhancement; 3D liver tumor model; Finite element model; HEPATOCELLULAR-CARCINOMA; EFFICACY; SAFETY;
D O I
10.1007/s10439-021-02734-x
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In the present study, we used a computational and experimental study in a 3D liver tumor model (LTM) to explore the tumor ablation enhancement of irreversible electroporation (IRE) by pre-heating with radiofrequency ablation (RFA) and elucidate the mechanism whereby this enhancement occurs. Three ablation protocols, including IRE alone, RFA45 -> IRE (with the pre-heating temperature of 45 degrees C), and RFA60 -> IRE (with the pre-heating temperature of 60 degrees C) were investigated. Both the thermal conductivity and electrical conductivity of the 3D LTM were characterized with the change in the pre-heating temperature. The results showed, compared to IRE alone, a significant increase in the tumor ablation volume (19.59 +/- 0.61 vs. 15.29 +/- 0.61 mm(3), p = 0.002 and 22.87 +/- 0.35 vs. 15.29 +/- 0.61 mm(3), p < 0.001) was observed with both RFA45 -> IRE and RFA60 -> IRE, leading to a decrease in lethal electric filed strength (8 and 17%, correspondingly). The mechanism can be attributed to the change of cell microenvironment by pre-heating and/or a synergistic effect of RFA and IRE. The proposed enhancing method might contribute to the improvement of interventional oncology in the treatment of large tumors close to critical organs (e.g., large blood vessels and bile ducts).
引用
收藏
页码:2126 / 2138
页数:13
相关论文
共 36 条
  • [1] A Three-Dimensional In Vitro Tumor Platform for Modeling Therapeutic Irreversible Electroporation
    Arena, Christopher B.
    Szot, Christopher S.
    Garcia, Paulo A.
    Rylander, Marissa Nichole
    Davalos, Rafael V.
    [J]. BIOPHYSICAL JOURNAL, 2012, 103 (09) : 2033 - 2042
  • [2] Irreversible Electroporation for Unresectable Hepatocellular Carcinoma: Initial Experience and Review of Safety and Outcomes
    Cheung, W.
    Kavnoudias, H.
    Roberts, S.
    Szkandera, B.
    Kemp, W.
    Thomson, K. R.
    [J]. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2013, 12 (03) : 233 - 241
  • [3] Effects of Microwave Ablation on Arterial and Venous Vasculature after Treatment of Hepatocellular Carcinoma
    Chiang, Jason
    Cristescu, Mircea
    Lee, Matthew H.
    Moreland, Anna
    Hinshaw, J. Louis
    Lee, Fred T.
    Brace, Christopher L.
    [J]. RADIOLOGY, 2016, 281 (02) : 617 - 624
  • [4] The effects of intense submicrosecond electrical pulses on cells
    Deng, JD
    Schoenbach, KH
    Buescher, ES
    Hair, PS
    Fox, PM
    Beebe, SJ
    [J]. BIOPHYSICAL JOURNAL, 2003, 84 (04) : 2709 - 2714
  • [5] Treatment Planning Optimization in Irreversible Electroporation for Complete Ablation of Variously Sized Cervical Tumors: A Numerical Study
    Ding, Lujia
    Moser, Michael
    Luo, Yigang
    Zhang, Wenjun
    Zhang, Bing
    [J]. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2021, 143 (01):
  • [6] First Human Trial of High-Frequency Irreversible Electroporation Therapy for Prostate Cancer
    Dong, Shoulong
    Wang, Haifeng
    Zhao, Yajun
    Sun, Yinghao
    Yao, Chenguo
    [J]. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2018, 17
  • [7] Controllable Moderate Heating Enhances the Therapeutic Efficacy of Irreversible Electroporation for Pancreatic Cancer
    Edelblute, Chelsea M.
    Hornef, James
    Burcus, Niculina I.
    Norman, Thomas
    Beebe, Stephen J.
    Schoenbach, Karl
    Heller, Richard
    Jiang, Chunqi
    Guo, Siqi
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [8] Engineering ToolBox, SPECIFIC HEAT SOME M
  • [9] Falk H., 2018, Acta Oncologica, V57, P311, DOI DOI 10.1080/0284186X.2017.1355109
  • [10] Temperature Dependence of High Frequency Irreversible Electroporation Evaluated in a 3D Tumor Model
    Fesmire, Christopher C.
    Petrella, Ross A.
    Fogle, Callie A.
    Gerber, David A.
    Xing, Lei
    Sano, Michael B.
    [J]. ANNALS OF BIOMEDICAL ENGINEERING, 2020, 48 (08) : 2233 - 2246