Minireview: Nanoparticles and the Immune System

被引：676
作者：
Zolnik, Banu S. [2 ]
Gonzalez-Fernandez, Africa [3 ,4 ]
Sadrieh, Nakissa [2 ]
Dobrovolskaia, Marina A. [1 ]
机构：
[1] NCI, Nanotechnol Characterizat Lab, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21703 USA
[2] US FDA, Ctr Drug Evaluat & Res, Off Pharmaceut Sci, Silver Spring, MD 20993 USA
[3] Univ Vigo, Area Inmunol, Vigo 36310, Pontevedra, Spain
[4] Univ Vigo, Unidad Compartida Complejo Hosp Univ Vigo, Vigo 36310, Pontevedra, Spain
来源：
ENDOCRINOLOGY | 2010年 / 151卷 / 02期
基金：
美国国家卫生研究院;
关键词：
ACCELERATED BLOOD CLEARANCE; ALBUMIN-BOUND PACLITAXEL; WALLED-CARBON-NANOTUBES; COMPLEMENT ACTIVATION; LIPID NANOPARTICLES; PEGYLATED LIPOSOMES; HYPERSENSITIVITY REACTIONS; PATHOTROPIC NANOPARTICLES; IMMUNOLOGICAL-PROPERTIES; CYTOKINE PRODUCTION;
D O I：
10.1210/en.2009-1082
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Today nanotechnology is finding growing applications in industry, biology, and medicine. The clear benefits of using nanosized products in various biological and medical applications are often challenged by concerns about the lack of adequate data regarding their toxicity. One area of interest involves the interactions between nanoparticles and the components of the immune system. Nanoparticles can be engineered to either avoid immune system recognition or specifically inhibit or enhance the immune responses. We review herein reported observations on nanoparticle-mediated immunostimulation and immunosuppression, focusing on possible theories regarding how manipulation of particle physicochemical properties can influence their interaction with immune cells to attain desirable immunomodulation and avoid undesirable immunotoxicity. (Endocrinology 151: 458-465, 2010)
引用
收藏
页码：458 / 465
页数：8
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