Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis

被引：30

作者：

Di Monta, Gianluca ^{[1
]}

Caraco, Corrado ^{[1
]}

Simeone, Ester ^{[2
]}

Grimaldi, Antonio Maria ^{[2
]}

Marone, Ugo ^{[1
]}

Di Marzo, Massimiliano ^{[1
]}

Vanella, Vito ^{[2
]}

Festino, Lucia ^{[2
]}

Palla, Marco ^{[2
]}

Mori, Stefano ^{[1
]}

Mozzillo, Nicola ^{[1
]}

Ascierto, Paolo Antonio ^{[2
]}

机构：

[1] Ist Nazl Studio & Cura Tumori Fdn G Pascale, Dept Surg Melanoma Soft Tissues Head & Neck Skin, Via Mariano Semmola, I-80131 Naples, Italy

[2] Ist Nazl Studio & Cura Tumori Fdn G Pascale, Unit Med Oncol & Innovat Therapy, Via Mariano Semmola, I-80131 Naples, Italy

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2017年 / 15卷

关键词：

Electrochemotherapy; Electroporation; Squamous cell carcinoma; STANDARD OPERATING PROCEDURES; NONMELANOMA HEAD; NECK CANCERS; ELECTRIC PULSES; BLEOMYCIN; TUMORS; METASTASES; EXPERIENCE; MANAGEMENT; CISPLATIN;

D O I：

10.1186/s12967-017-1186-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Extensive squamous cell carcinoma has few therapeutic options. In such cases, electrochemotherapy involving electroporation combined with antineoplastic drug appears to be a new potential option and may be considered as an alternative treatment. The aim of this retrospective single-center study was to evaluate electrochemotherapy efficacy in treatment of locally advanced stage III squamous cell carcinoma, in which surgical procedures would have entailed wide tissue sacrifice. Methods: Clinical features, treatment response, and adverse effects were evaluated in 22 patients treated with electrochemotherapy with intravenous injection of bleomycin for extensive stage III cutaneous squamous cell carcinoma. Treatment of cutaneous lesions were performed according to the European Standard Operating Procedures of Electrochemotherapy. Results: Overall response to electrochemotherapy treatment was observed in 18 (81.8%) patients. Clinical response with necrosis of tumor mass was observed from the first session and lasted for all follow up period that ranged between 5 and 48 months with a median of 34 months. Overall the treatment was well tolerated with a very low complication rate. Conclusions: Electrochemotherapy represents a safe and effective therapeutic approach, associated with a good tolerability.

引用

页数：8

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