Effects of therapeutic probiotics on modulation of microRNAs

被引：51

作者：

Davoodvandi, Amirhossein ^{[1
]}

Marzban, Havva ^{[2
]}

Goleij, Pouya ^{[3
]}

Sahebkar, Amirhossein ^{[4
,5
]}

Morshedi, Korosh ^{[6
]}

Rezaei, Samaneh ^{[7
,8
]}

Mahjoubin-Tehran, Maryam ^{[7
,8
]}

Tarrahimofrad, Hossein ^{[9
]}

Hamblin, Michael R. ^{[10
]}

Mirzaei, Hamed ^{[11
]}

机构：

[1] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran

[2] Univ Tehran, Fac Vet Med, Dept Vet Pathol, Tehran, Iran

[3] Sana Inst Higher Educ, Fac Biol, Dept Genet, Sari, Iran

[4] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[5] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

[6] Kashan Univ Med Sci, Fac Med, Kashan, Iran

[7] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran

[8] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol, Mashhad, Razavi Khorasan, Iran

[9] Natl Inst Genet Engn & Biotechnol NIGEB, Dept Anim Biotechnol, Tehran, Iran

[10] Massachusetts Gen Hosp, Wellman Ctr Photomed, Harvard Med Sch, 40 Blossom St, Boston, MA 02114 USA

[11] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran

来源：

CELL COMMUNICATION AND SIGNALING | 2021年 / 19卷 / 01期

关键词：

MicroRNAs; Probiotics; Biomarkers; Cancer; Inflammatory bowel disease; Supplements; LACTOBACILLUS-RHAMNOSUS GG; IRRITABLE-BOWEL-SYNDROME; COLI-NISSLE; 1917; SEASONAL ALLERGIC RHINITIS; COLORECTAL-CANCER PATIENTS; MICROBIAL CELL PREPARATION; RANDOMIZED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; MESENCHYMAL STEM-CELLS; QUALITY-OF-LIFE;

D O I：

10.1186/s12964-020-00668-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Probiotics are beneficial bacteria that exist within the human gut, and which are also present in different food products and supplements. They have been investigated for some decades, due to their potential beneficial impact on human health. Probiotics compete with pathogenic microorganisms for adhesion sites within the gut, to antagonize them or to regulate the host immune response resulting in preventive and therapeutic effects. Therefore, dysbiosis, defined as an impairment in the gut microbiota, could play a role in various pathological conditions, such as lactose intolerance, gastrointestinal and urogenital infections, various cancers, cystic fibrosis, allergies, inflammatory bowel disease, and can also be caused by antibiotic side effects. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate gene expression in a post-transcriptional manner. miRNAs are biochemical biomarkers that play an important role in almost all cellular signaling pathways in many healthy and disease states. For the first time, the present review summarizes current evidence suggesting that the beneficial properties of probiotics could be explained based on the pivotal role of miRNAs.

引用

页数：22

共 201 条

[1] Cell free preparations of probiotics exerted antibacterial and antibiofilm activities against multidrug resistant E. coli [J].