Simultaneous measurement of 23 plasma cytokines in late-life depression

被引：13

作者：

Lee, Kang Soo ^{[8
,9
]}

Chung, Ji Hyung ^{[7
]}

Lee, Kyung Hye ^{[7
]}

Shin, Min-Jeong ^{[6
]}

Oh, Byoung Hoon ^{[5
]}

Lee, Soo Hyung ^{[4
]}

Hong, Chang Hyung ^{[1
,2
,3
]}

机构：

[1] Ajou Univ, Sch Med, Suwon 443749, South Korea

[2] Ajou Univ Hosp, Memory Impairment Ctr, Suwon, South Korea

[3] Ajou Univ, Sch Med, Dept Psychiat, Ajou Inst Aging, Suwon 441749, South Korea

[4] Seoul Med Ctr, Dept Family Med, Seoul, South Korea

[5] Yonsei Univ, Coll Med, Dept Psychiat, Inst Behav Sci Med, Seoul, South Korea

[6] Yeungnam Univ, Dept Food & Nutr, Gyongsan, South Korea

[7] Yonsei Univ, Yonsei Univ Res Inst Sci Aging, Seoul 120749, South Korea

[8] Yonsei Univ, Dept Med, Grad Sch, Seoul 120749, South Korea

[9] Pochon CHA Univ, Coll Med, Dept Psychiat, Songnam, South Korea

来源：

NEUROLOGICAL SCIENCES | 2009年 / 30卷 / 05期

关键词：

Cytokine; Late-life depression; Interleukin-1; alpha; Bioplex; Plasma; Vascular risk factors; DORSOLATERAL PREFRONTAL CORTEX; MAJOR DEPRESSION; INFLAMMATORY MARKERS; SYSTEM; EXPRESSION; BRAIN;

D O I：

10.1007/s10072-009-0091-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

According to the cytokine hypothesis of depression, cytokines play key roles in the behavioral, neuroendocrinal, and neurochemical features of depression. In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1 alpha) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1 alpha levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1 alpha may play important roles in the pathogenesis of late-life depression.

引用

页码：435 / 438

页数：4

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