New directions of activity-based sensing for in vivo NIR imaging

被引：70

作者：

East, Amanda K. ^{[1
]}

Lucero, Melissa Y. ^{[1
]}

Chan, Jefferson ^{[1
]}

机构：

[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Chem, Urbana, IL 61801 USA

来源：

CHEMICAL SCIENCE | 2021年 / 12卷 / 10期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Activity-based - Biological process - Native environment - Near-infrared imaging - NIR Imaging - Small molecules;

D O I：

10.1039/d0sc03096a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In vivo imaging is a powerful approach to study biological processes. Beyond cellular methods, in vivo studies allow for biological stimuli (small molecules or proteins) to be studied in their native environment. This has the potential to aid in the discovery of new biology and guide the development of diagnostics and therapies for diseases. To ensure selectivity and an observable readout, the probe development field is shifting towards activity-based sensing (ABS) approaches and near-infrared (NIR) imaging modalities. This perspective will highlight recent in vivo ABS applications that utilize NIR imaging platforms.

引用

页码：3393 / 3405

页数：13

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