ApoE ε4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

被引：5
|
作者：
Andres Kauffman, Marcelo [1 ,2 ]
Pereira-de-Silva, Nahuel [1 ]
Consalvo, Damian [1 ]
Kochen, Silvia [1 ]
机构：
[1] Hosp Ramos Mejia, Div Neurol, Ctr Epilepsia, CEFYBO,CONICET, RA-1221 Buenos Aires, DF, Argentina
[2] Sanatorio Franchin, Serv Neurol, Neurogenet Lab, Buenos Aires, DF, Argentina
来源：
EPILEPSY RESEARCH | 2009年 / 85卷 / 2-3期
关键词：
ApoE; Temporal lobe epilepsy; Gene; Polymorphism; GENETIC ASSOCIATION; THERAPEUTIC TARGET; DISEASE; SUSCEPTIBILITY; METAANALYSIS;
D O I：
10.1016/j.eplepsyres.2009.03.012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A previous report found an association between ApoE isoforms and postictal confusion in medically intractable temporal lobe epilepsy (TLE). We performed a molecular epidemiology study in an independent sample of 77 TLE patients. We failed to replicate the original allelic association between ApoE epsilon 4 allele and postictal confusion in our population (chi(2) = 1.67; d.f. = 1; p=0.2). Thus, the association between ApoE epsilon 4 allele and postictal confusion still needs to be fully investigated in different and independent populations. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：311 / 313
页数：3
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