4-Hydroxy-3-methoxy-5-nitroacetophenone (5-nitroapocynin)

被引：2

作者：

Babu, Sainath ^{[1
,2
,3
]}

Raghavamenon, Achuthan C. ^{[1
,2
,3
,4
]}

Fronczek, Frank R.

Uppu, Rao M. ^{[1
,2
,3
]}

机构：

[1] So Univ, Dept Environm Toxicol, Baton Rouge, LA 70813 USA

[2] So Univ, Hlth Res Ctr, Baton Rouge, LA 70813 USA

[3] A&M Coll, Baton Rouge, LA 70813 USA

[4] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

NADPH OXIDASE; PROTEIN NITRATION; APOCYNIN; INHIBITOR;

D O I：

10.1107/S160053680903390X

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The title molecule, C9H9NO5, is close to planar (r.m.s. deviation from the mean plane of the non-H atoms = 0.058 angstrom). The OH group forms a bifurcated O-H center dot center dot center dot(O,O) hydrogen bond, with the intramolecular component to a nitro O atom and the intermolecular component to a keto O atom, the latter resulting in chains along [20 (1) over bar]. A C-H center dot center dot center dot O interaction reinforces the packing.

引用

收藏

页码：O2292 / U3249

页数：13

相关论文

共 19 条

[1] SIR97:: a new tool for crystal structure determination and refinement [J].

Altomare, A ;

Burla, MC ;

Camalli, M ;

Cascarano, GL ;

Giacovazzo, C ;

Guagliardi, A ;

Moliterni, AGG ;

Polidori, G ;

Spagna, R .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1999, 32 :115-119

[2]

Farrujia LJ., 1997, J APPL CRYSTALLOGR, V30, P565, DOI [10.1107/S0021889897003117, DOI 10.1107/S0021889897003117]

[3] Antioxidants and inflammatory disease: Synthetic and natural antioxidants with anti-inflammatory activity [J].

Geronikaki, Athina A. ;

Gavalas, Antonios M. .

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2006, 9 (06) :425-442

[4] NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction [J].

Hayashi, T ;

Juliet, PAR ;

Kano-Hayashi, H ;

Tsunekawa, T ;

Dingqunfang, D ;

Sumi, D ;

Matsui-Hirai, H ;

Fukatsu, A ;

Iguchi, A .

DIABETES OBESITY & METABOLISM, 2005, 7 (04) :334-343

[5] Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant [J].

Heumueller, Sabine ;

Wind, Sven ;

Barbosa-Sicard, Eduardo ;

Schmidt, Harald H. H. W. ;

Busse, Rudi ;

Schroeder, Katrin ;

Brandes, Ralf P. .

HYPERTENSION, 2008, 51 (02) :211-217

[6]

MATES JM, 2009, MINI REV MED CH 0801

[7] Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice [J].

Muijsers, RBR ;

van Ark, I ;

Folkerts, G ;

Koster, AS ;

van Oosterhout, AJM ;

Postma, DS ;

Nijkamp, FP .

BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134 (02) :434-440

[8]

Nonius, 2000, COLLECT

[9] Processing of X-ray diffraction data collected in oscillation mode [J].

Otwinowski, Z ;

Minor, W .

MACROMOLECULAR CRYSTALLOGRAPHY, PT A, 1997, 276 :307-326

[10]

Raghavamenon AC, 2009, FASEB J, V23