Understanding the Heterogeneity of Obesity and the Relationship to the Brain-Gut Axis

被引：12
作者：
Hung, Tony K. W. [1 ,2 ]
Dong, Tien S. [1 ,2 ,3 ,4 ,5 ]
Chen, Zixi [1 ,6 ]
Elashoff, David [1 ,7 ,8 ]
Sinsheimer, Janet S. [7 ,8 ,9 ]
Jacobs, Jonathan P. [1 ,2 ,3 ,4 ,5 ,6 ]
Lagishetty, Venu [1 ,4 ]
Vora, Priten [1 ,6 ]
Stains, Jean [1 ,2 ,3 ,6 ]
Mayer, Emeran A. [1 ,2 ,3 ,4 ,6 ,10 ]
Gupta, Arpana [1 ,2 ,3 ,4 ,6 ]
机构：
[1] Univ Calif Los Angeles, Div Hematol & Oncol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Vatche & Tamar Manoukian Div Digest Dis, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Microbiome Ctr, Los Angeles, CA 90095 USA
[5] Vet Adm Greater Los Angeles Healthcare Syst, Div Gastroenterol Hepatol & Parenteral Nutr, Los Angeles, CA 90095 USA
[6] Univ Calif Los Angeles, G Oppenheimer Ctr Neurobiol Stress & Resilience, Los Angeles, CA 90095 USA
[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Computat Med, Los Angeles, CA 90095 USA
[8] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA
[9] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
[10] Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA
来源：
NUTRIENTS | 2020年 / 12卷 / 12期
基金：
美国国家卫生研究院;
关键词：
obesity; microbiome; brain-gut axis; amino acids; metabolites; heterogeneity; precision medicine; Hispanic; health disparity; diet; BODY-MASS INDEX; DIET-INDUCED OBESITY; FOOD ADDICTION; UNITED-STATES; IMMUNE-SYSTEM; HEART-DISEASE; RISK-FACTORS; MICROBIOTA; PREVALENCE; ACCULTURATION;
D O I：
10.3390/nu12123701
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Obesity is best understood as a multifactorial metabolic imbalances disorder. In a cross-sectional study, we aimed to explore sociodemographic and dietary determinants of obesity in relation to brain-gut homeostasis among overweight and obese individuals. Multivariate logistic regression models were used to examine obesity and its association with sociodemographic and dietary factors. Biological variables examined included the gut microbiome, fecal amino acid metabolites and brain structural volumes. Among 130 participants, there were higher odds of obesity if individuals were Hispanic (adjusted odds ratio (aOR) 1.56, p = 0.014). Compared to non-Hispanics, Hispanics differed in gut microbial composition (p = 0.046) with lower microbial species richness (Chao1) (p = 0.032) and evenness (Shannon) (p = 0.0029). Fourteen of the twenty fecal amino acids including branch-chain- and aromatic- amino acids were increased among Hispanics (q < 0.05). Brain structural volumes in reward regions were decreased in Hispanics (pallidum, q = 0.036; brainstem, q = 0.011). Correlation patterns suggest complex brain-gut interactions differ by Hispanic ethnicity. In conclusion, Hispanics expressed a unique brain-gut microbial signature, which was associated with obesity despite sociodemographic and dietary differences. Addressing ethnic disparities guided by biologic phenotypes may unlock novel understanding of obesity heterogeneity and treatment strategies.
引用
收藏
页码：1 / 22
页数：22
相关论文
共 130 条
[1]   Do healthy behaviors decline with greater acculturation?: Implications for the Latino mortality paradox [J].
Abraído-Lanza, AF ;
Chao, MT ;
Flórez, KR .
SOCIAL SCIENCE & MEDICINE, 2005, 61 (06) :1243-1255
[2]   Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function [J].
Agusti, Ana ;
Garcia-Pardo, Maria P. ;
Lopez-Almela, Inmaculada ;
Campillo, Isabel ;
Maes, Michael ;
Romani-Perez, Marina ;
Sanz, Yolanda .
FRONTIERS IN NEUROSCIENCE, 2018, 12
[3]   Human Gut Microbiome and Risk for Colorectal Cancer [J].
Ahn, Jiyoung ;
Sinha, Rashmi ;
Pei, Zhiheng ;
Dominianni, Christine ;
Wu, Jing ;
Shi, Jianxin ;
Goedert, James J. ;
Hayes, Richard B. ;
Yang, Liying .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2013, 105 (24) :1907-1911
[4]  
American Cancer Society, 2018, CANC FACTS FIG HISP
[5]  
Andolina D., 2017, KEY ROLE AMYGDALA ST, DOI [10.5772/67826, DOI 10.5772/67826]
[6]  
Anfal AD., 2020, Obes Med, V19, P100246, DOI [10.1016/j.obmed.2020.100246, DOI 10.1016/J.OBMED.2020.100246]
[7]  
[Anonymous], 2020, AD OB FACTS
[8]   Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults [J].
Bagheri, Minoo ;
Djazayery, Abolghasem ;
Farzadfar, Farshad ;
Qi, Lu ;
Yekaninejad, Mir Saeed ;
Aslibekyan, Stella ;
Chamari, Maryam ;
Hassani, Hossein ;
Koletzko, Berthold ;
Uhl, Olaf .
LIPIDS IN HEALTH AND DISEASE, 2019, 18 (1)
[9]   Prevention of chronic disease in the 21st century: elimination of the leading preventable causes of premature death and disability in the USA [J].
Bauer, Ursula E. ;
Briss, Peter A. ;
Goodman, Richard A. ;
Bowman, Barbara A. .
LANCET, 2014, 384 (9937) :45-52
[10]   Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms [J].
Berthoud, Hans-Rudolf ;
Munzberg, Heike ;
Morrison, Christopher D. .
GASTROENTEROLOGY, 2017, 152 (07) :1728-1738
12345678910