Pd-Catalyzed regioselective synthesis of 2,6-disubstituted pyridines through denitrogenation of pyridotriazoles and 3,8-diarylation of imidazo[1,2-a]pyridines

被引：28

作者：

Joshi, Abhisek ^{[1
]}

Semwal, Rashmi ^{[1
]}

Suresh, Eringathodi ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] Cent Salt & Marine Chem Res Inst, CSIR, Acad Sci & Innovat Res, Bhavnagar 364002, Gujarat, India

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 73期

关键词：

ONE-POT SYNTHESIS; C-H ARYLATION; TRANSANNULATION REACTION; MODULAR SYNTHESIS; PALLADIUM; COPPER; ALKENYLATION; HETEROCYCLES; ALKYNES; BONDS;

D O I：

10.1039/c9cc05953a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of 2,6-disubstituted pyridines from pyridotriazoles through palladium-catalyzed aerobic oxidative denitrogenative reactions has been described. Denitrogenation of arylated pyridotriazoles generates metal-carbene intermediates in situ and provides selectively 6-aryl-2-benzoylpyridines. The same conditions have been extended to regioselective C-3 and C-8 diarylation of several imidazo[1,2-a]pyridines.

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收藏

页码：10888 / 10891

页数：4

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