Can Natural Products Exert Neuroprotection without Crossing the Blood-Brain Barrier?

被引:28
作者
Leclerc, Manon [1 ,2 ,3 ,4 ]
Dudonne, Stephanie [3 ,4 ]
Calon, Frederic [1 ,2 ,3 ,4 ]
机构
[1] Univ Laval, Fac Pharm, Quebec City, PQ G1V 0A6, Canada
[2] Univ Laval, CHU Quebec, Ctr Rech, Axe Neurosci, Quebec City, PQ G1V 4G2, Canada
[3] Inst Nutr & Aliments Fonct INAF, Quebec City, PQ G1V 0A6, Canada
[4] NutriNeuro France INAF Canada, OptiNutriBrain Lab Int Associe, Quebec City, PQ G1V 0A6, Canada
基金
加拿大健康研究院;
关键词
blood– brain barrier; central nervous system; bioavailability; polyphenols; omega-3 polyunsaturated fatty acids; gut– brain axis; POLYUNSATURATED FATTY-ACID; CENTRAL-NERVOUS-SYSTEM; GUT MICROBIOTA COMPOSITION; ALPHA-LINOLENIC ACID; DOCOSAHEXAENOIC ACID; ALZHEIMERS-DISEASE; MOUSE MODEL; AMYLOID-BETA; PARKINSONS-DISEASE; COGNITIVE DEFICITS;
D O I
10.3390/ijms22073356
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The scope of evidence on the neuroprotective impact of natural products has been greatly extended in recent years. However, a key question that remains to be answered is whether natural products act directly on targets located in the central nervous system (CNS), or whether they act indirectly through other mechanisms in the periphery. While molecules utilized for brain diseases are typically bestowed with a capacity to cross the blood-brain barrier, it has been recently uncovered that peripheral metabolism impacts brain functions, including cognition. The gut-microbiota-brain axis is receiving increasing attention as another indirect pathway for orally administered compounds to act on the CNS. In this review, we will briefly explore these possibilities focusing on two classes of natural products: omega-3 polyunsaturated fatty acids (n-3 PUFAs) from marine sources and polyphenols from plants. The former will be used as an example of a natural product with relatively high brain bioavailability but with tightly regulated transport and metabolism, and the latter as an example of natural compounds with low brain bioavailability, yet with a growing amount of preclinical and clinical evidence of efficacy. In conclusion, it is proposed that bioavailability data should be sought early in the development of natural products to help identifying relevant mechanisms and potential impact on prevalent CNS disorders, such as Alzheimer's disease.
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页数:21
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共 235 条
[1]   Blood-brain barrier structure and function and the challenges for CNS drug delivery [J].
Abbott, N. Joan .
JOURNAL OF INHERITED METABOLIC DISEASE, 2013, 36 (03) :437-449
[2]   Structure and function of the blood-brain barrier [J].
Abbott, N. Joan ;
Patabendige, Adjanie A. K. ;
Dolman, Diana E. M. ;
Yusof, Siti R. ;
Begley, David J. .
NEUROBIOLOGY OF DISEASE, 2010, 37 (01) :13-25
[3]   Brain Uptake of a Fluorescent Vector Targeting the Transferrin Receptor: A Novel Application of in Situ Brain Perfusion [J].
Alata, Wael ;
Paris-Robidas, Sarah ;
Emond, Vincent ;
Bourasset, Fanchon ;
Calon, Frederic .
MOLECULAR PHARMACEUTICS, 2014, 11 (01) :243-253
[4]   Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery [J].
Alavijeh M.S. ;
Chishty M. ;
Qaiser M.Z. ;
Palmer A.M. .
NeuroRX, 2005, 2 (4) :554-571
[5]   Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial [J].
Andrieu, Sandrine ;
Guyonnet, Sophie ;
Coley, Nicola ;
Cantet, Christelle ;
Bonnefoy, Marc ;
Bordes, Serge ;
Bories, Lawrence ;
Cufi, Marie-Noelle ;
Dantoine, Thierry ;
Dartigues, Jean-Francois ;
Desclaux, Francoise ;
Gabelle, Audrey ;
Gasnier, Yannick ;
Pesce, Alain ;
Sudres, Kristel ;
Touchon, Jacques ;
Robert, Philippe ;
Rouaud, Olivier ;
Legrand, Philippe ;
Payoux, Pierre ;
Caubere, Jean-Paul ;
Weiner, Michael ;
Carrie, Isabelle ;
Ousset, Pierre-Jean ;
Vellas, Bruno .
LANCET NEUROLOGY, 2017, 16 (05) :377-389
[6]   5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models [J].
Angelino, Donato ;
Carregosa, Diogo ;
Domenech-Coca, Cristina ;
Savi, Monia ;
Figueira, Ines ;
Brindani, Nicoletta ;
Jang, Saebyeol ;
Lakshman, Sukla ;
Molokin, Aleksey ;
Urban, Joseph E., Jr. ;
Davis, Cindy D. ;
Brito, Maria Alexandra ;
Kim, Kwang Sik ;
Brighenti, Furio ;
Curti, Claudio ;
Blade, Cinta ;
del Bas, Josep M. ;
Stilli, Donatella ;
Solano-Aguilar, Gloria, I ;
dos Santos, Claudia Nunes ;
del Rio, Daniele ;
Mena, Pedro .
NUTRIENTS, 2019, 11 (11)
[7]   The role of diet in preventing and reducing cognitive decline [J].
Angeloni, Cristina ;
Businaro, Rita ;
Vauzour, David .
CURRENT OPINION IN PSYCHIATRY, 2020, 33 (04) :432-438
[8]   Natural Products and Neuroprotection [J].
Angeloni, Cristina ;
Vauzour, David .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (22)
[9]   Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice [J].
Anhe, Fernando F. ;
Nachbar, Renato T. ;
Varin, Thibault V. ;
Trottier, Jocelyn ;
Dudonne, Stephanie ;
Le Barz, Melanie ;
Feutry, Perrine ;
Pilon, Genevieve ;
Barbier, Olivier ;
Desjardins, Yves ;
Roy, Denis ;
Marette, Andre .
GUT, 2019, 68 (03) :453-464
[10]   A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss [J].
Anhe, Fernando F. ;
Nachbar, Renato T. ;
Varin, Thibault V. ;
Vilela, Vanessa ;
Dudonne, Stephanie ;
Pilon, Genevieve ;
Fournier, Maryse ;
Lecours, Marc-Andre ;
Desjardins, Yves ;
Roy, Denis ;
Levy, Emile ;
Marette, Andre .
MOLECULAR METABOLISM, 2017, 6 (12) :1563-1573