Stable solid-supported leucoanthocyanidin variants for flavanoid biosynthesis elucidation

被引：11
作者：
Deffieux, Denis [1 ,2 ]
Gaudrel-Grosay, Sophie [1 ,2 ]
Grelard, Axelle [2 ]
Chalumeau, Celine [1 ,2 ]
Quideau, Stephane [1 ,2 ]
机构：
[1] Univ Bordeaux, Inst Mol Sci, CNRS, UMR 5255, F-33405 Talence, France
[2] Inst Europeen Chim & Biol, F-33607 Pessac, France
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 47期
关键词：
Flavanoids; Leucoanthocyanidins; Anthocyanidins; Proanthocyanidins; Biosynthesis; ANTHOCYANIDIN SYNTHASE; PROANTHOCYANIDIN BIOSYNTHESIS; MOLECULAR-CLONING; DERIVATIVES; CONVERSION; REDUCTASE;
D O I：
10.1016/j.tetlet.2009.09.045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Remarkable progress toward the complete elucidation of the biosynthesis of flavanoids has been accomplished during the last decade, but the final steps presumably involving the transformation of leucoanthocyanidins, which are highly unstable when free in aqueous solution into both anthocyanidins and proanthocyanidins still remain to be fully understood. Herein is described the synthesis of stabilized solid-supported leucoanthocyanidin variants that should serve as valuable tools for in vitro studies aimed at investigating the metabolism of these seemingly fleeting common precursors of two main classes of flavanoids. (C) 2009 Elsevier Ltd All lights reserved
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页码：6567 / 6571
页数：5
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