Four-Component Synthesis of Fully Substituted 1,2,4-Triazoles

被引：90

作者：

Staben, Steven T. ^{[1
]}

Blaquiere, Nicole ^{[1
]}

机构：

[1] Genentech Inc, Discovery Chem Grp, San Francisco, CA 94080 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 02期

关键词：

carbonylation; C-C coupling; homogeneous catalysis; multicomponent reactions; nitrogen heterocycles; CROSS-COUPLING REACTIONS; COPPER-CATALYZED ARYLATION; CARBON-MONOXIDE; BORONIC ACIDS; PALLADIUM; HETEROCYCLE; ALTERNATIVES; OXADIAZOLES; EFFICIENT; IMINES;

D O I：

10.1002/anie.200905897

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

"Chemical Equation Presented" All 4 one: Palladium-catalyzed carbonylation initiates a highly regioselective triazole synthesis. In this four-partner protocol, the aryl halide, amidine, and hydrazine partners are easily varied, allowing the synthesis of fully substituted 1,2,4-triazoles in a modular fashion. This methodology is demonstrated with the synthesis of druglike and/or pharmaceutically relevant molecules such as deferasirox. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：325 / 328

页数：4

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