OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes

被引：18

作者：

Chu, Dinh-Toi ^{[1
,2
,3
,4
]}

Tao, Yang ^{[5
]}

Tasken, Kjetil ^{[1
,2
,6
,7
,8
]}

机构：

[1] Univ Oslo, Nord European Mol Biol Lab Partnership, Ctr Mol Med Norway, POB 1137, N-0318 Oslo, Norway

[2] Oslo Univ Hosp, POB 1137, N-0318 Oslo, Norway

[3] Duy Tan Univ, Inst Res & Dev, K7-25 Quang Trung, Danang, Vietnam

[4] Hanoi Natl Univ Educ, Fac Biol, Hanoi, Vietnam

[5] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing, Jiangsu, Peoples R China

[6] KG Jebsen Inflammat Res Ctr, Oslo, Norway

[7] Univ Oslo, Oslo, Norway

[8] Oslo Univ Hosp, Dept Infect Dis, Oslo, Norway

来源：

HORMONE AND METABOLIC RESEARCH | 2017年 / 49卷 / 04期

关键词：

OPA1; AKAP; cAMP; lipid metabolism; brown adipocyte; white adipocyte; BROWN ADIPOSE-TISSUE; PPAR-GAMMA; MITOCHONDRIAL BIOGENESIS; GENE-EXPRESSION; PUNICIC ACID; OXIDATIVE STRESS; COLD-EXPOSURE; WHITE FAT; PROTEIN; OBESITY;

D O I：

10.1055/s-0043-100384

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1). In brown adipocytes indirect evidence support the notion that OPA1 regulation of fission serves to increase thermogenesis, which thereby contributes to dissipation of energy. In white adipocytes, OPA1 located on lipid droplets serves as a gatekeeper to control lipolysis induced by adrenergic agonists. However, the function of OPA1 in lipolysis and thermogenesis in inducible brown adipocytes (brite/beige cells) remains elusive. Here we discuss the role of OPA1 in lipid metabolism.

引用

页码：276 / 285

页数：10

共 104 条

[1] Lipolysis in adipocytes [J].

Ahmadian, Maryam ;

Wang, Yuhui ;

Sul, Hei Sook .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (05) :555-559

[2] A NOVEL REGULATORY PATHWAY OF BROWN FAT THERMOGENESIS - RETINOIC ACID IS A TRANSCRIPTIONAL ACTIVATOR OF THE MITOCHONDRIAL UNCOUPLING PROTEIN GENE [J].

ALVAREZ, R ;

DEANDRES, J ;

YUBERO, P ;

VINAS, O ;

MAMPEL, T ;

IGLESIAS, P ;

GIRALT, M ;

VILLARROYA, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (10) :5666-5673

[3] Insulin resistance by TNF-α is associated with mitochondrial dysfunction in 3T3-L1 adipocytes and is ameliorated by punicic acid, a PPARγ agonist [J].

Anusree, S. S. ;

Nisha, V. M. ;

Priyanka, A. ;

Raghu, K. G. .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2015, 413 (0C) :120-128

[4] β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse [J].

Atit, Radhika ;

Sgaier, Sema K. ;

Mohamed, Othman A. ;

Taketo, Makoto M. ;

Dufort, Daniel ;

Joyner, Alexandra L. ;

Niswander, Lee ;

Conlon, Ronald A. .

DEVELOPMENTAL BIOLOGY, 2006, 296 (01) :164-176

[5] Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice [J].

Bassaganya-Riera, Josep ;

DiGuardo, Margaret ;

Climent, Montse ;

Vives, Cristina ;

Carbo, Adria ;

Jouni, Zeina E. ;

Einerhand, Alexandra W. C. ;

O'Shea, Marianne ;

Hontecillas, Raquel .

BRITISH JOURNAL OF NUTRITION, 2011, 106 (06) :878-886

[6] GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK [J].

Beiroa, Daniel ;

Imbernon, Monica ;

Gallego, Rosalia ;

Senra, Ana ;

Herranz, Daniel ;

Villarroya, Francesc ;

Serrano, Manuel ;

Ferno, Johan ;

Salvador, Javier ;

Escalada, Javier ;

Dieguez, Carlos ;

Lopez, Miguel ;

Fruehbeck, Gema ;

Nogueiras, Ruben .

DIABETES, 2014, 63 (10) :3346-3358

[7] Down-regulation of beta(3) adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor [J].

Bengtsson, T ;

Redegren, K ;

Strosberg, AD ;

Nedergaard, J ;

Cannon, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (52) :33366-33375

[8] Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents [J].

Bjorndal, Bodil ;

Burri, Lena ;

Staalesen, Vidar ;

Skorve, Jon ;

Berge, Androlf K. .

JOURNAL OF OBESITY, 2011, 2011

[9] BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality [J].

Boon, Mariette R. ;

van den Berg, Sjoerd A. A. ;

Wang, Yanan ;

van den Bossche, Jan ;

Karkampouna, Sofia ;

Bauwens, Matthias ;

De Saint-Hubert, Marijke ;

van der Horst, Geertje ;

Vukicevic, Slobodan ;

de Winther, Menno P. J. ;

Havekes, Louis M. ;

Jukema, J. Wouter ;

Tamsma, Jouke T. ;

van der Pluijm, Gabri ;

van Dijk, Ko Willems ;

Rensen, Patrick C. N. .

PLOS ONE, 2013, 8 (09)

[10] Brown Adipose Tissue and the Cold War Against Obesity [J].

Calvani, Riccardo ;

Leeuwenburgh, Christiaan ;

Marzetti, Emanuele .

DIABETES, 2014, 63 (12) :3998-4000

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