The role of dendritic cells in tumor microenvironments and their uses as therapeutic targets

被引：44

作者：

Kim, Chae Won ^{[1
]}

Kim, Kyun-Do ^{[2
]}

Lee, Heung Kyu ^{[1
,3
]}

机构：

[1] Korea Adv Inst Sci & Technol KAIST, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea

[2] Korea Res Inst Chem Technol, Ctr Convergent Res Emerging Virus Infect, Daejeon 34114, South Korea

[3] Korea Adv Inst Sci & Technol, Biomed Res Ctr, Daejeon 34141, South Korea

来源：

BMB REPORTS | 2021年 / 54卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Cancer immunology; Cancer therapy; Dendritic cells; ANTIGEN-PRESENTING CELLS; I INTERFERON; ANTITUMOR IMMUNITY; NECROSIS-FACTOR; LYMPH-NODES; CANCER; RESPONSES; ACTIVATION; CD8(+); RECEPTOR;

D O I：

10.5483/BMBRep.2021.54.1.224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cells (DC), which consist of several different subsets, specialize in antigen presentation and are critical for mediating the innate and adaptive immune responses. DC subsets can be classified into conventional, plasmacytoid, and monocyte-derived DC in the tumor microenvironment, and each subset plays a different role. Because of the role of intratumoral DCs in initiating antitumor immune responses with tumor-derived antigen presentation to T cells, DCs have been targeted in the treatment of cancer. By regulating the functionality of DCs, several DC-based immunotherapies have been developed, including administration of tumor-derived antigens and DC vaccines. In addition, DCs participate in the mechanisms of classical cancer therapies, such as radiation therapy and chemotherapy. Thus, regulating DCs is also important in improving current cancer therapies. Here, we will discuss the role of each DC subset in antitumor immune responses, and the current status of DC-related cancer therapies.

引用

页码：31 / 43

页数：13

共 110 条

[1] Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity [J].

Alloatti, Andres ;

Rookhuizen, Derek C. ;

Joannas, Leonel ;

Carpier, Jean-Marie ;

Iborra, Salvador ;

Magalhaes, Joao G. ;

Yatim, Nader ;

Kozik, Patrycja ;

Sancho, David ;

Albert, Matthew L. ;

Amigorena, Sebastian .

JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (08) :2231-2241

[2] Immunotherapeutic effects of intratumoral nanoplexed poly I:C [J].

Angela Aznar, M. ;

Planelles, Lourdes ;

Perez-Olivares, Mercedes ;

Molina, Carmen ;

Garasa, Saray ;

Etxeberria, Inaki ;

Perez, Guiomar ;

Rodriguez, Inmaculada ;

Bolanos, Elixabet ;

Lopez-Casas, Pedro ;

Rodriguez-Ruiz, Maria E. ;

Perez-Gracia, Jose L. ;

Marquez-Rodas, Ivan ;

Teijeira, Alvaro ;

Quintero, Marisol ;

Melero, Ignacio .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7

[3] Clinical use of dendritic cells for cancer therapy [J].

Anguille, Sebastien ;

Smits, Evelien L. ;

Lion, Eva ;

van Tendeloo, Viggo F. ;

Berneman, Zwi N. .

LANCET ONCOLOGY, 2014, 15 (07) :E257-E267

[4] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[5] Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL [J].

Aspord, Caroline ;

Leccia, Marie-Therese ;

Charles, Julie ;

Plumas, Joel .

CANCER IMMUNOLOGY RESEARCH, 2013, 1 (06) :402-415

[6] Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines [J].

Bakdash, Ghaith ;

Buschow, Sonja I. ;

Gorris, Mark A. J. ;

Halilovic, Altuna ;

Hato, Stanleyson V. ;

Skold, Annette E. ;

Schreibelt, Gerty ;

Sittig, Simone P. ;

Torensma, Ruurd ;

Duiveman-de Boer, Tjitske ;

Schroeder, Christoph ;

Smits, Evelien L. ;

Figdor, Carl G. ;

de Vries, I. Jolanda M. .

CANCER RESEARCH, 2016, 76 (15) :4332-4346

[7] Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer [J].

Balachandran, Vinod P. ;

Luksza, Marta ;

Zhao, Julia N. ;

Makarov, Vladimir ;

Moral, John Alec ;

Remark, Romain ;

Herbst, Brian ;

Askan, Gokce ;

Bhanot, Umesh ;

Senbabaoglu, Yasin ;

Wells, Daniel K. ;

Cary, Charles Ian Ormsby ;

Grbovic-Huezo, Olivera ;

Attiyeh, Marc ;

Medina, Benjamin ;

Zhang, Jennifer ;

Loo, Jennifer ;

Saglimbeni, Joseph ;

Abu-Akeel, Mohsen ;

Zappasodi, Roberta ;

Riaz, Nadeem ;

Smoragiewicz, Martin ;

Kelley, Z. Larkin ;

Basturk, Olca ;

Goenen, Mithat ;

Levine, Arnold J. ;

Allen, Peter J. ;

Fearon, Douglas T. ;

Merad, Miriam ;

Gnjatic, Sacha ;

Iacobuzio-Donahue, Christine A. ;

Wolchok, Jedd D. ;

DeMatteo, Ronald P. ;

Chan, Timothy A. ;

Greenbaum, Benjamin D. ;

Merghoub, Taha ;

Leach, Steven D. .

NATURE, 2017, 551 (7681) :512-+

[8] A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments [J].

Barry, Kevin C. ;

Hsu, Joy ;

Broz, Miranda L. ;

Cueto, Francisco J. ;

Binnewies, Mikhail ;

Combes, Alexis J. ;

Nelson, Amanda E. ;

Loo, Kimberly ;

Kumar, Raj ;

Rosenblum, Michael D. ;

Alvarado, Michael D. ;

Wolf, Denise M. ;

Bogunovic, Dusan ;

Bhardwaj, Nina ;

Daud, Adil, I ;

Ha, Patrick K. ;

Ryan, William R. ;

Pollack, Joshua L. ;

Samad, Bushra ;

Asthana, Saurabh ;

Chan, Vincent ;

Krummel, Matthew F. .

NATURE MEDICINE, 2018, 24 (08) :1178-1191

[9] E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs [J].

Bi, Enguang ;

Li, Rong ;

Bover, Laura C. ;

Li, Haiyan ;

Su, Pan ;

Ma, Xingzhe ;

Huang, Chunjian ;

Wang, Qiang ;

Liu, Lintao ;

Yang, Maojie ;

Lin, Zhijuan ;

Qian, Jianfei ;

Fu, Weijun ;

Liu, Yong-Jun ;

Yi, Qing .

JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (11) :4821-4831

[10] Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity [J].

Binnewies, Mikhail ;

Mujal, Adriana M. ;

Pollack, Joshua L. ;

Combes, Alexis J. ;

Hardison, Emily A. ;

Barry, Kevin C. ;

Tsui, Jessica ;

Ruhland, Megan K. ;

Kersten, Kelly ;

Abushawish, Marwan A. ;

Spasic, Marko ;

Giurintano, Jonathan P. ;

Chan, Vincent ;

Daud, Adil, I ;

Ha, Patrick ;

Ye, Chun J. ;

Roberts, Edward W. ;

Krummel, Matthew F. .

CELL, 2019, 177 (03) :556-+

← 1 2 3 4 5 6 7 8 9 10 →