Genetic association of VDR polymorphisms and multiple myeloma susceptibility: a case control study

Objective: The aim of this study was to investigate whether the vitamin D receptor (VDR) gene polymorphisms were associated with multiple myeloma (MM) susceptibility in the Chinese Han population. Methods: Two polymorphisms rs2228570 (FokI) and rs731236 (TaqI) in VDR gene were genotyped in 113 MM patients and 117 healthy controls. Chi-square test was employed to compare the genotype and allele distributions of each polymorphism between case and control groups. The strength of the association between VDR gene polymorphisms and MM risk was evaluated based on the odds ratio (OR) with corresponding 95% confidence interval (CI). Results: Significant association was found between VDR gene polymorphisms and MM risk. The TT genotype frequency of rs2228570 significantly increased in case group compared with controls, revealing that rs2228570 TT genotype positively associated with MM risk (P= 0.031, OR= 2.407, 95% CI= 1.075-5.393). Individuals carrying T allele showed higher risk to be affected by MM by 1.463 fold versus the C allele carriers (P= 0.043, OR= 1.463, 95% CI= 1.0112.118). Mutant C allele of rs731236 was a risk factor for the onset of MM (P= 0.012, OR= 2.407696, 95% CI= 1.2135.990). Conclusion: All results suggested that VDR gene two polymorphisms rs2228570 and rs731236 might be important genetic factors in MM susceptibility in the Chinese Han population.