Nut consumption and the prevalence and severity of non-alcoholic fatty liver disease

被引：15

作者：

Semmler, Georg ^{[1
]}

Bachmayer, Sebastian ^{[1
]}

Wernly, Sarah ^{[1
]}

Wernly, Bernhard ^{[2
]}

Niederseer, David ^{[3
]}

Huber-Schonauer, Ursula ^{[1
]}

Stickel, Felix ^{[4
]}

Aigner, Elmar ^{[5
]}

Datz, Christian ^{[1
]}

机构：

[1] Paracelsus Med Univ Salzburg, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, Salzburg, Austria

[2] Paracelsus Med Univ Salzburg, Dept Med 2, Salzburg, Austria

[3] Univ Hosp Zurich, Dept Cardiol, Zurich, Switzerland

[4] Univ Hosp Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland

[5] Paracelsus Med Univ Salzburg, Dept Med 1, Salzburg, Austria

来源：

PLOS ONE | 2020年 / 15卷 / 12期

关键词：

RELATIVE VALIDITY; GERMAN PART; RISK; NAFLD; DIET; REPRODUCIBILITY; ASSOCIATIONS; INFLAMMATION; FIBROSIS; HEALTH;

D O I：

10.1371/journal.pone.0244514

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. However, the influence on the prevalence and severity of non-alcoholic fatty liver disease (NAFLD) has yet to be evaluated. Methods 4655 subjects were included as part of a colorectal carcinoma screening program (SAKKOPI) between 07/2010 and 07/2019 and analyzed 2020. Patients were characterized using biochemical and metabolic parameters, as well as a detailed questionnaire on dietary habits. The diagnosis of NAFLD was established using abdominal ultrasound. Consumption of nuts was graded as: no consumption or <1 time/week, 1-6 times/week, 1 time/day and >= 2 times/day. Results Mean age was 58.5 +/- 9.8years with a mean BMI of 26.5 +/- 4.7kg/m(2). 2058 (44.2%) patients suffered from the metabolic syndrome, 2407 (51.6%) had arterial hypertension, 2287 (49.1%) showed prediabetes/diabetes, 1854 (39.4%) had dyslipidemia and 1984 patients (43.5%) were diagnosed with NAFLD. Prevalence of metabolic syndrome (1219 [48.7%] vs. 605 [40.2%] vs. 189 [37.4%] vs. 45 [31.7%], p<0.001) and NALFD (1184 [48.1%] vs. 594 [40.7%] vs. 158 [31.7%] vs. 48 [34.0%], p<0.001). On multivariable logistic regression analysis adjusting for potential confounders and dietary patterns, nut consumption >= 1time/day was inversely associated with NAFLD in the overall cohort (adjusted Odds ratio[aOR]: 0.719 [95%CI:0.558-0.926], p = 0.011). However, following subgroup analysis, this inverse association was only confirmed in male patients (aOR: 0.589 [95%CI: 0.411-0.844], p = 0.004) but not in females (aOR: 0.886 [95%CI: 0.616-1.275], p = 0.515). Moreover, patients who consumed nuts 1-6 times/week had a significantly lower prevalence of advanced fibrosis (Fib-4 score >2.67: aOR: 0.551 [95%CI: 0.338-0.898], p = 0.017; Forns-Index >6.9: aOR: 0.585 [95%CI: 0.402-0.850], p = 0.005). Conclusions Nut consumption might exert beneficial effects on the prevalence of NAFLD in males. The negative association with advanced fibrosis warrants further investigation.

引用

页数：13

共 63 条

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