Antihyperlipidemic Compounds from the Fruit of Piper longum L.

被引：49
|
作者：
Jin, Zhuang [1 ]
Borjihan, Gereltu [1 ]
Zhao, Ruiguo [1 ]
Sun, Zhaorigetu [1 ]
Hammond, Gerald B. [2 ]
Uryu, Toshiyuki [3 ]
机构：
[1] Inner Mongolia Univ, Inst Macromol Chem & Mongolian Med, Hohhot 010021, Peoples R China
[2] Univ Louisville, Dept Chem, Louisville, KY 40292 USA
[3] Teikyo Univ Sci & Technol, Yamanashi 4090193, Japan
来源：
PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 08期
关键词：
antihyperlipidemic activity; Piper longum L; piperlonguminine; piperine; piperonaline; RATS; REDUCTASE;
D O I：
10.1002/ptr.2630
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码：1194 / 1196
页数：3
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