Patients with implanted continuous, nonpulsatile, left ventricular assist devices (LVADs) have increased the occurrence of gastrointestinal bleeding (GIB). Although the pathophysiology is multifactorial, there are few treatments beyond supportive care. Octreotide acetate is a somatostatin analog that reduces GIB in various patient populations. However, there are sparse case series that suggest octreotide acetate may reduce GIB in LVAD patients. This 10 patient, 28 week phase I study evaluated the safety and tolerability of octreotide acetate long-acting release (LAR) 20 mg depot injection every 4 weeks until week 16 after LVAD placement. Secondary aims were occurrence of GIB and measurement of vascular endothelial growth factor, fibrinogen, von Willebrand factor, and platelet aggregation across the study period. Ten patients were enrolled, and eight completed the study. The two study dropouts were not related to octreotide. None of the patients experienced side effects or safety concerns related to octreotide nor did GIB occur in the study population. Vascular endothelial growth factor levels were maintained in the reference range throughout the duration of the study. There did appear to be laboratory evidence of acquired von Willebrand syndrome, with mildly low platelet aggregation studies. In conclusion, octreotide acetate LAR 20 mg depot injection was safe and effective in this population.
机构:
Univ Alabama Birmingham, Div Gastroenterol & Hepatol, Birmingham, AL USAUniv Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
Brown, Colin
;
Subramanian, Venkataraman
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机构:
Univ Nottingham, Nottingham Digest Dis Ctr, Nottingham NG7 2RD, EnglandUniv Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
Subramanian, Venkataraman
;
Wilcox, C. Mel
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机构:
Univ Alabama Birmingham, Div Gastroenterol & Hepatol, Birmingham, AL USAUniv Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
Wilcox, C. Mel
;
Peter, Shajan
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机构:
Univ Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Div Gastroenterol & Hepatol, Birmingham, AL USAUniv Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
机构:
Washington Univ, Dept Gastroenterol, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Dept Gastroenterol, 660 South Euclid Ave, St Louis, MO 63110 USA
Cushing, Kelly
;
Kushnir, Vladimir
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机构:
Washington Univ, Dept Gastroenterol, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Dept Gastroenterol, 660 South Euclid Ave, St Louis, MO 63110 USA
机构:
Univ Alabama Birmingham, Div Gastroenterol & Hepatol, Birmingham, AL USAUniv Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
Brown, Colin
;
Subramanian, Venkataraman
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nottingham, Nottingham Digest Dis Ctr, Nottingham NG7 2RD, EnglandUniv Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
Subramanian, Venkataraman
;
Wilcox, C. Mel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Div Gastroenterol & Hepatol, Birmingham, AL USAUniv Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
Wilcox, C. Mel
;
Peter, Shajan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Div Gastroenterol & Hepatol, Birmingham, AL USAUniv Alabama Birmingham, Dept Med Gastroenterol & Hepatol, Birmingham, AL 35294 USA
机构:
Washington Univ, Dept Gastroenterol, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Dept Gastroenterol, 660 South Euclid Ave, St Louis, MO 63110 USA
Cushing, Kelly
;
Kushnir, Vladimir
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Dept Gastroenterol, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Dept Gastroenterol, 660 South Euclid Ave, St Louis, MO 63110 USA