Extreme hypoxia tolerance of naked mole-rat brain

被引：130

作者：

Larson, John ^{[1
,2
]}

Park, Thomas J. ^{[2
,3
]}

机构：

[1] Univ Illinois, Dept Psychiat, Inst Psychiat, Chicago, IL 60612 USA

[2] Univ Illinois, Dept Biol Sci, Chicago, IL 60612 USA

[3] Univ Illinois, Lab Integrat Neurosci, Chicago, IL 60612 USA

来源：

NEUROREPORT | 2009年 / 20卷 / 18期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

adenosine; anoxia; hippocampus; hypoxia; paired-pulse facilitation; synaptic transmission; HIPPOCAMPAL SLICES; HETEROCEPHALUS-GLABER; TEMPERATURE; SENSITIVITY; DAMAGE;

D O I：

10.1097/WNR.0b013e32833370cf

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mammalian brains have extremely high levels of aerobic metabolism and typically suffer irreversible damage after brief periods of oxygen deprivation such as occur during stroke or cardiac arrest Here we report that brain tissue from naked mole-rats, rodents that live in a chronically low-oxygen environment is remarkably resistant to hypoxia: naked mole-rat neurons maintain synaptic transmission much longer than mouse neurons and can recover from periods of anoxia exceeding 30 min. We suggest that brain tolerance to hypoxia may result from slowed or arrested brain development in these extremely long-lived animals. NeuroReport 20:1634-1637 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：1634 / 1637

页数：4

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