Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model

被引：28

作者：

Duchamp, Margaux ^{[1
,2
]}

Liu, Tingting ^{[1
,3
]}

van Genderen, Anne M. ^{[1
,4
]}

Kappings, Vanessa ^{[1
,5
]}

Oklu, Rahmi ^{[6
]}

Ellisen, Leif W. ^{[7
]}

Zhang, Yu Shrike ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA

[2] Ecole Polytech Fed Lausanne, Dept Bioengn, CH-1015 Lausanne, Switzerland

[3] Second Mil Med Univ, Changhai Hosp, Ctr Clin Expt, Shanghai 200433, Peoples R China

[4] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacol, NL-3584 CG Utrecht, Netherlands

[5] Karlsruhe Inst Technol, Inst Toxicol & Genet, D-76131 Karlsruhe, Germany

[6] Mayo Clin, Div Vasc & Intervent Radiol, Scottsdale, AZ 85259 USA

[7] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

来源：

BIOTECHNOLOGY JOURNAL | 2019年 / 14卷 / 10期

基金：

美国国家卫生研究院;

关键词：

bioprinting; breast cancer; cancer model; ductal carcinoma; hydrogel; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; INTRATUMOR HETEROGENEITY; 3D MODELS; HYDROGELS; EVOLUTION; STATISTICS; MEDICINE; NETWORKS; CELLS;

D O I：

10.1002/biot.201700703

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer tissue engineering has remained challenging due to the limitations of the conventional biofabrication techniques to model the complex tumor microenvironment. Here, the utilization of a sacrificial bioprinting strategy is reported to generate the biomimetic mammary duct-like structure within a hydrogel matrix, which is further populated with breast cancer cells, to model the genesis of ductal carcinoma and its subsequent outward invasion. This bioprinted mammary ductal carcinoma model provides a proof-of-concept demonstration of the value of using the sacrificial bioprinting technique for engineering biologically relevant cancer models, which may be possibly extended to other cancer types where duct-like structures are involved.

引用

页数：9

共 70 条

[1] Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration [J].

Acerbi, I. ;

Cassereau, L. ;

Dean, I. ;

Shi, Q. ;

Au, A. ;

Park, C. ;

Chen, Y. Y. ;

Liphardt, J. ;

Hwang, E. S. ;

Weaver, V. M. .

INTEGRATIVE BIOLOGY, 2015, 7 (10) :1120-1134

[2] Examining the utility of patient-derived xenograft mouse models [J].

Aparicio, Samuel ;

Hidalgo, Manuel ;

Kung, Andrew L. .

NATURE REVIEWS CANCER, 2015, 15 (05) :311-316

[3] The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity [J].

Barretina, Jordi ;

Caponigro, Giordano ;

Stransky, Nicolas ;

Venkatesan, Kavitha ;

Margolin, Adam A. ;

Kim, Sungjoon ;

Wilson, Christopher J. ;

Lehar, Joseph ;

Kryukov, Gregory V. ;

Sonkin, Dmitriy ;

Reddy, Anupama ;

Liu, Manway ;

Murray, Lauren ;

Berger, Michael F. ;

Monahan, John E. ;

Morais, Paula ;

Meltzer, Jodi ;

Korejwa, Adam ;

Jane-Valbuena, Judit ;

Mapa, Felipa A. ;

Thibault, Joseph ;

Bric-Furlong, Eva ;

Raman, Pichai ;

Shipway, Aaron ;

Engels, Ingo H. ;

Cheng, Jill ;

Yu, Guoying K. ;

Yu, Jianjun ;

Aspesi, Peter, Jr. ;

de Silva, Melanie ;

Jagtap, Kalpana ;

Jones, Michael D. ;

Wang, Li ;

Hatton, Charles ;

Palescandolo, Emanuele ;

Gupta, Supriya ;

Mahan, Scott ;

Sougnez, Carrie ;

Onofrio, Robert C. ;

Liefeld, Ted ;

MacConaill, Laura ;

Winckler, Wendy ;

Reich, Michael ;

Li, Nanxin ;

Mesirov, Jill P. ;

Gabriel, Stacey B. ;

Getz, Gad ;

Ardlie, Kristin ;

Chan, Vivien ;

Myer, Vic E. .

NATURE, 2012, 483 (7391) :603-607

[4] Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs [J].

Bertassoni, Luiz E. ;

Cecconi, Martina ;

Manoharan, Vijayan ;

Nikkhah, Mehdi ;

Hjortnaes, Jesper ;

Cristino, Ana Luiza ;

Barabaschi, Giada ;

Demarchi, Danilo ;

Dokmeci, Mehmet R. ;

Yang, Yunzhi ;

Khademhosseini, Ali .

LAB ON A CHIP, 2014, 14 (13) :2202-2211

[5] A liver-on-a-chip platform with bioprinted hepatic spheroids [J].

Bhise, Nupura S. ;

Manoharan, Vijayan ;

Massa, Solange ;

Tamayol, Ali ;

Ghaderi, Masoumeh ;

Miscuglio, Mario ;

Lang, Qi ;

Zhang, Yu Shrike ;

Shin, Su Ryon ;

Calzone, Giovanni ;

Annabi, Nasim ;

Shupe, Thomas D. ;

Bishop, Colin E. ;

Atala, Anthony ;

Dokmeci, Mehmet R. ;

Khademhosseini, Ali .

BIOFABRICATION, 2016, 8 (01)

[6] Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure [J].

Bischel, Lauren L. ;

Beebe, David J. ;

Sung, Kyung E. .

BMC CANCER, 2015, 15

[7] The causes and consequences of genetic heterogeneity in cancer evolution [J].

Burrell, Rebecca A. ;

McGranahan, Nicholas ;

Bartek, Jiri ;

Swanton, Charles .

NATURE, 2013, 501 (7467) :338-345

[8] Interrogating open issues in cancer precision medicine with patient-derived xenografts [J].

Byrne, Annette T. ;

Alferez, Denis G. ;

Amant, Frederic ;

Annibali, Daniela ;

Arribas, Joaquin ;

Biankin, Andrew V. ;

Bruna, Alejandra ;

Budinska, Eva ;

Caldas, Carlos ;

Chang, David K. ;

Clarke, Robert B. ;

Clevers, Hans ;

Coukos, George ;

Dangles-Marie, Virginie ;

Eckhardt, S. Gail ;

Gonzalez-Suarez, Eva ;

Hermans, Els ;

Hidalgo, Manuel ;

Jarzabek, Monika A. ;

de Jong, Steven ;

Jonkers, Jos ;

Kemper, Kristel ;

Lanfrancone, Luisa ;

Maelandsmo, Gunhild Mari ;

Marangoni, Elisabetta ;

Marine, Jean-Christophe ;

Medico, Enzo ;

Norum, Jens Henrik ;

Palmer, Hector G. ;

Peeper, Daniel S. ;

Pelicci, Pier Giuseppe ;

Piris-Gimenez, Alejandro ;

Roman-Roman, Sergio ;

Rueda, Oscar M. ;

Seoane, Joan ;

Serra, Violeta ;

Soucek, Laura ;

Vanhecke, Dominique ;

Villanueva, Alberto ;

Vinolo, Emilie ;

Bertotti, Andrea ;

Trusolino, Livio .

NATURE REVIEWS CANCER, 2017, 17 (04) :254-268

[9]

Chirikos Thomas N, 2002, Cancer Control, V9, P59

[10] Lessons from patient-derived xenografts for better in vitro modeling of human cancer [J].

Choi, Stephen Yiu Chuen ;

Lin, Dong ;

Gout, Peter W. ;

Collins, Colin C. ;

Xu, Yong ;

Wang, Yuzhuo .

ADVANCED DRUG DELIVERY REVIEWS, 2014, 79-80 :222-237

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