Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics

被引：164

作者：

Zhu, Susi ^{[1
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Guo, Yeye ^{[1
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Zhang, Xu ^{[1
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Liu, Hong ^{[1
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Yin, Mingzhu ^{[1
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Chen, Xiang ^{[1
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Peng, Cong ^{[1
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机构：

[1] Cent South Univ, Xiangya Hosp, Dept Dermatol, Xiangya Rd 87, Changsha 410008, Hunan, Peoples R China

[2] Hunan Key Lab Skin Canc & Psoriasis, Changsha, Hunan, Peoples R China

[3] Hunan Engn Res Ctr Skin Hlth & Dis, Changsha, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Clin Res Ctr Canc Immunotherapy, Changsha, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Res Ctr Mol Metabol, Changsha, Hunan, Peoples R China

[6] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China

来源：

CANCER LETTERS | 2021年 / 503卷

基金：

国家自然科学基金国际合作与交流项目; 中国国家自然科学基金;

关键词：

Pyruvate kinase M2; Long noncoding RNA; Tumor microenvironment; Inhibitors; Agonists; TUMOR MICROENVIRONMENT; GENE-TRANSCRIPTION; UP-REGULATION; CELLS; GROWTH; EXPRESSION; METABOLISM; PROMOTES; PROLIFERATION; DERIVATIVES;

D O I：

10.1016/j.canlet.2020.11.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various cancers and promoted proliferation and metastasis of tumor cells. The errant expression of PKM2 has inspired people to investigate the function of PKM2 and the therapeutic potential in cancer. In addition, some studies have shown that the upregulation of PKM2 in tumor tissues is associated with the altered expression of lncRNAs and the poor survival. Therefore, researchers have begun to unravel the specific molecular mechanisms of lncRNA-mediated PKM2 expression in cancer metabolism. As the tumor microenvironment (TME) is essential in tumor development, it is necessary to identify the role of PKM2 in TME. In this review, we will introduce the role of PKM2 in different cancers as well as TME, and summarize the molecular mechanism of PKM2-related lncRNAs in cancer metabolism. We expect that this work will lead to a better understanding of the molecular mechanisms of PKM2 that may help in developing therapeutic strategies in clinic for researchers.

引用

页码：240 / 248

页数：9

共 114 条

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