A new method for the synthesis of unsymmetrical bis-aldols by the samarium(II) iodide-mediated aldol reaction of aldehydes with aryl or alkyl oxiranyl ketones

被引：25
作者：
Mukaiyama, T [1 ]
Arai, H [1 ]
Shiina, I [1 ]
机构：
[1] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Toyko 1628601, Japan
来源：
CHEMISTRY LETTERS | 2000年 / 05期
关键词：
D O I：
10.1246/cl.2000.580
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Unsymmetrical alkyl or aryl 2-hydroxy-1(1-hydroxyalkyl)-alkyl ketones (bis-aldols) were synthesized by the samarium(II) iodide-mediated aldol reaction of aldehydes with alkyl or aryl oxiranyl ketones. Bis-aldols were formed via the aldol reaction of aldehydes with samarium enolates generated by epoxy-fragmentation of oxiranyl ketones using two moles of samarium(II) iodide.
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页码：580 / 581
页数：2
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