LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the Pl3K/AKT pathway

被引：43
作者：
Li, ZhiZhen [1 ,2 ,3 ]
Chen, YuanYuan [1 ,2 ,3 ]
Wang, XuAn [1 ,2 ,3 ]
Zhang, HongChen [1 ,2 ,3 ]
Zhang, Yijian [1 ,2 ,3 ]
Gao, YaoHui [1 ,2 ,3 ]
Weng, Mingzhe [1 ,2 ,3 ]
Wang, Lei [1 ,2 ,3 ]
Liang, HaiBin [1 ,2 ,3 ]
Li, MaoLan [1 ,2 ,3 ]
Zhang, Fei [1 ,2 ,3 ]
Zhao, Shuai [1 ,2 ,3 ]
Liu, Shibo [1 ,2 ,3 ]
Cao, Yang [1 ,2 ,3 ]
Shu, Yijun [1 ,2 ,3 ]
Bao, Runfa [1 ,2 ,3 ]
Zhou, Jian [1 ,2 ,3 ]
Liu, Xiyong [1 ,2 ,3 ]
Yan, Yun [1 ,2 ,3 ]
Zhen, Lei [1 ,2 ,3 ]
Dong, Qian [1 ,2 ,3 ]
Liu, Yingbin [1 ,2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Surg, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Lab Gen Surg, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Inst Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China
来源：
CANCER LETTERS | 2016年 / 372卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Gallbladder cancer; LASP-1; S100P; Proliferation; Metastasis; Cell cycle; SH3; PROTEIN-1; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; BREAST-CANCER; SNP DISCOVERY; MIGRATION; SURVIVAL; LIM; OVEREXPRESSION; LOCALIZATION;
D O I：
10.1016/j.canlet.2016.01.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LASP-1 is an actin-binding protein that regulates cytoskeletal dynamics and cell migration. LASP-1 was previously identified in a cDNA library from metastatic breast cancer samples. This protein has since been detected in multiple human cancers, including liver cancer, gastric cancer and pancreatic cancer. S100P is a small calcium-binding protein in the 5100 protein family that regulates cellular, physiological and pathological processes in various cancers. However, the clinical significance of LASP-1 and S100P expression in gallbladder cancer (GBC) is not yet clear. In our study, we focused on the clinical significance, biological function and mechanism of LASP-1 in gallbladder cancer and detected LASP-1 and S100P overexpression in GBC tissues. The expression of LASP-1 was significantly correlated with poor prognosis in GBC patients (P < 0.05). Furthermore, down-regulation of LASP-1 expression resulted in the obvious inhibition of proliferation and migration and caused cell cycle arrest by down-regulating S100P via the PI3K/AKT pathway; in mice, tumor volume was signifidantly decreased. In conclusion, LASP-1 may act as an oncogene to regulate the expression of S100P to influence cellular functions in GBC. LASP-1 could serve as a genetic treatment target in GBC patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：239 / 250
页数：12
相关论文
共 33 条
  • [21] Root extract of Hemsleya amabilis Diels suppresses renal cell carcinoma cell growth through inducing apoptosis and G2/M phase arrest via PI3K/AKT signaling pathway
    Li, Kai
    You, Ganhua
    Jiang, Kehua
    Wang, Rongpin
    Li, Wuchao
    Meng, Yonglu
    Fang, Yinyi
    Chen, Weiming
    Zhu, Guohua
    Song, Jukun
    Wang, Wei
    Su, Hao
    Hu, Bin
    Sun, Fa
    Jia, Zhenyu
    Li, Can
    Zhu, Jianguo
    JOURNAL OF ETHNOPHARMACOLOGY, 2024, 318
  • [22] The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells
    Li, Jin-Ping
    Yang, Yin-Xue
    Liu, Qi-Lun
    Pan, Shu-Ting
    He, Zhi-Xu
    Zhang, Xueji
    Yang, Tianxin
    Chen, Xiao-Wu
    Wang, Dong
    Qiu, Jia-Xuan
    Zhou, Shu-Feng
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2015, 9 : 1627 - 1652
  • [23] Andrographolide Induces G2/M Cell Cycle Arrest and Apoptosis in Human Glioblastoma DBTRG-05MG Cell Line via ERK1/2 /c-Myc/p53 Signaling Pathway
    Othman, Nurul Syamimi
    Azman, Daruliza Kernain Mohd
    MOLECULES, 2022, 27 (19):
  • [24] Gallic acid induces G2/M phase cell cycle arrest via regulating 14-3-3β release from Cdc25C and Chk2 activation in human bladder transitional carcinoma cells
    Ou, Ting-Tsz
    Wang, Chau-Jong
    Lee, Yung-Shu
    Wu, Cheng-Hsun
    Lee, Huei-Jane
    MOLECULAR NUTRITION & FOOD RESEARCH, 2010, 54 (12) : 1781 - 1790
  • [25] Induction of G2/M Cell Cycle Arrest via p38/p21Waf1/Cip1-Dependent Signaling Pathway Activation by Bavachinin in Non-Small-Cell Lung Cancer Cells
    Pai, Jih-Tung
    Hsu, Ming-Wei
    Leu, Yann-Lii
    Chang, Kuo-Ting
    Weng, Meng-Shih
    MOLECULES, 2021, 26 (17):
  • [26] Wild pink bayberry free phenolic extract induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest through p38/MAPK and PI3K/Akt pathway in MDA-MB-231 cancer cells
    Xia, Wen
    Gong, Ersheng
    Lin, Yanyun
    Zheng, Bisheng
    Yang, Wenhan
    Li, Tong
    Zhang, Sheng
    Li, Peng
    Liu, Ruihai
    FOOD SCIENCE AND HUMAN WELLNESS, 2023, 12 (05) : 1510 - 1518
  • [27] JS']JS-K induces G2/M phase cell cycle arrest and apoptosis in A549 and H460 cells via the p53/p21WAF1/CIP1 and p27KIP1 pathways
    Song, Zeqing
    Yin, Yongxin
    Hao, Siyuan
    Wei, Jianmao
    Liu, Bin
    Huang, Xiaojie
    Gao, Chenfeng
    Zhu, Runzhi
    Liao, Weiguo
    Cai, De
    ONCOLOGY REPORTS, 2019, 41 (06) : 3475 - 3487
  • [28] Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
    Pan, Shu-Ting
    Qin, Yiru
    Zhou, Zhi-Wei
    He, Zhi-Xu
    Zhang, Xueji
    Yang, Tianxin
    Yang, Yin-Xue
    Wang, Dong
    Qiu, Jia-Xuan
    Zhou, Shu-Feng
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2015, 9 : 1601 - 1626
  • [29] Salmonella Shows Anti-Cancer Influences in Human Colon Cancer Cells by Promoting Apoptosis and G0/G1 Phase Cell Cycle Arrest via PI3K/AKT/mTOR Pathway Inhibition
    Zhang, Bingling
    Fang, Ting
    Li, Sheng
    Xiang, Lan
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2022, 36 (06) : 2203 - 2209
  • [30] The Chalcone Flavokawain B Induces G2/M Cell-Cycle Arrest and Apoptosis in Human Oral Carcinoma HSC-3 Cells through the Intracellular ROS Generation and Downregulation of the Akt/p38 MAPK Signaling Pathway
    Hseu, You-Cheng
    Lee, Meng-Shiou
    Wu, Chi-Rei
    Cho, Hsin-Ju
    Lin, Kai-Yuan
    Lai, Guan-Hua
    Wang, Sheng-Yang
    Kuo, Yueh-Hsiung
    Kumar, K. J. Senthil
    Yang, Hsin-Ling
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 60 (09) : 2385 - 2397
1234