Synthesis of planar chiral isoquinolinone-fused ferrocenes through palladium-catalyzed C-H functionalization reaction

被引：18

作者：

Liu, Lantao ^{[1
,3
,4
]}

Liu, Huihui ^{[2
]}

Zuo, Zhenzhen ^{[4
]}

Zhang, An-An ^{[1
]}

Li, Zhongyi ^{[1
]}

Meng, Tuanjie ^{[1
]}

Wu, Wei ^{[2
]}

Hua, Yuanzhao ^{[4
]}

Mao, Guoliang ^{[2
]}

机构：

[1] Shangqiu Normal Univ, Henan Engn Lab Green Synth Pharmaceut, Coll Chem & Chem Engn, Shangqiu 476000, Peoples R China

[2] Northeast Petr Univ, Coll Chem & Chem Engn, Daqing 163318, Peoples R China

[3] Peking Univ, Coll Chem, Beijing Natl Lab Mol Sci BNLMS, Beijing 100871, Peoples R China

[4] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

(S; S)-Me-BI-DIME; Palladium; Asymmetric catalysis; C-H functionalization; Planar chiral ferrocenes; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC CATALYSIS; ARYLATION; LIGANDS; ACCESS; DERIVATIVES; SILYLATION; ANNULATION; GENERATION;

D O I：

10.1016/j.cclet.2020.10.034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(S,S)-Me-BI-DIME/Pd(0)-catalyzed ennantioselective C-H functionalization of N-ferrocenyl o-bromo-benzanilides has been realized, affording isoquinolinone-fused ferrocenes with up to 97% ee. The products can be transformed into planar chiral ferrocenyl monophosphines, which demonstrate their preliminary application. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：239 / 242

页数：4

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