Complete cDNA coding sequence of the HLA-DRB1*1405 allele

被引：4
|
作者：
Kohsaka, H
Nasu, K
Matsushita, S
Miyasaka, N
机构：
[1] Tokyo Med & Dent Univ, Grad Sch, Dept Bioregulatory Med & Rheumatol, Bunkyo Ku, Tokyo 1138519, Japan
[2] Saitama Med Sch, Dept Allergy & Immunol, Moroyama, Saitama 3500495, Japan
来源：
DNA SEQUENCE | 2002年 / 13卷 / 06期
关键词：
cDNA; coding sequence; DRB1*1405; HLA; nucleotide sequence;
D O I：
10.1080/1042517021000041822
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cloning report of complete coding region of HLA-DRB1*1405 has never appeared in the literature. We have isolated and sequenced it from a B cell line with a DRB1*1405/1502 genotype. The sequence information of this gene and previously published DRB1 genes for the other DR serotypes facilitated us to find that the cytoplasmic domain sequences of DRB1 genes fall into three groups. It is known that antigen presenting cells are differentially activated when products of different MHC class II genes are triggered. Functional analyses would discern if these allelic differences in the cytoplasmic domain are of functional significance.
引用
收藏
页码：359 / 361
页数：3
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