Intracellular DNA recognition

被引：290

作者：

Hornung, Veit ^{[1
]}

Latz, Eicke ^{[2
,3
]}

机构：

[1] Univ Bonn, Inst Clin Chem & Pharmacol, Univ Hosp, D-53127 Bonn, Germany

[2] Univ Bonn, Inst Innate Immun, Univ Hosp, D-53127 Bonn, Germany

[3] Univ Massachusetts, Div Infect Dis & Immunol, Sch Med, Worcester, MA 01605 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 02期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; INNATE IMMUNE-RESPONSES; INDEPENDENT GENE INDUCTION; DENDRITIC CELL ACTIVATION; MYCOBACTERIUM-BOVIS BCG; DOUBLE-STRANDED-RNA; CYTOSOLIC DNA; RIG-I; SYNTHETIC OLIGONUCLEOTIDES; CYTOPLASMIC DNA;

D O I：

10.1038/nri2690

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recognition of nucleic acids is one strategy by which cells can detect infectious agents. As life is ultimately determined by the existence of nucleic acids, this defence strategy has evolved in many different organisms and operates effectively in many different cell types. Here, we review the recent progress in our understanding of the molecular mechanisms by which DNA activates cells to induce inflammation and antimicrobial immunity. DNA can be detected in different cellular compartments and can induce a range of cellular responses, such as an antiviral response and pyroptotic cell death together with the maturation and release of active interleukin-1 beta.

引用

页码：123 / 130

页数：8

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