Circadian Function in Multiple Cell Types Is Necessary for Proper Timing of the Preovulatory LH Surge

被引:24
作者
Bittman, Eric L. [1 ,2 ]
机构
[1] Univ Massachusetts, Dept Biol, 221 Morrill S,611 N Pleasant, Amherst, MA 01003 USA
[2] Univ Massachusetts, Program Neurosci & Behav, 221 Morrill S,611 N Pleasant, Amherst, MA 01003 USA
基金
美国国家卫生研究院;
关键词
circadian; luteinizing hormone; Bmal1; vasopressin; kisspeptin; GnRH; VASOACTIVE-INTESTINAL-PEPTIDE; LUTEINIZING-HORMONE SURGE; ESTRADIOL-TREATED RATS; SUPRACHIASMATIC NUCLEUS; KISSPEPTIN NEURONS; GNRH NEURONS; GONADOTROPIN-SECRETION; PREOPTIC AREA; FEMALE MICE; CLOCK;
D O I
10.1177/0748730419873511
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The timing of the preovulatory surge of luteinizing hormone (LH), which occurs on the evening of proestrus in female mice, is determined by the circadian system. The identity of cells that control the phase of the LH surge is unclear: evidence supports a role of arginine vasopressin (AVP) cells of the suprachiasmatic nucleus (SCN), but it is not known whether vasopressinergic neurons are necessary or sufficient to account for circadian control of ovulation. Among other cell types, evidence also suggests important roles of circadian function of kisspeptin cells of the anteroventral periventricular nucleus (AvPV) and gonadotropin-releasing hormone (GnRH) neurons of the preoptic area (POA), whose discharge is immediately responsible for the discharge of LH from the anterior pituitary. The present studies used an ovariectomized, estradiol-treated preparation to determine critical cell types whose clock function is critical to the timing of LH secretion. As expected, the LH surge occurred at or shortly after ZT12 in control mice. In further confirmation of circadian control, the surge was advanced by 2 h in tau mutant animals. The timing of the surge was altered to varying degrees by conditional deletion of Bmal1 in AVP(Cre), Kiss(CreBAC), and GnRH(CreBAC) mice. Excision of the mutant Cnsk1e (tau) allele in AVP neurons resulted in a reversion of the surge to the ZT12. Conditional deletion of Bmal1 in Kiss1 or GnRH neurons had no noticeable effect on locomotor rhythms, but targeting of AVP neurons produced variable effects on circadian period that did not always correspond to changes in the phase of LH secretion. The results indicate that circadian function in multiple cell types is necessary for proper timing of the LH surge.
引用
收藏
页码:622 / 633
页数:12
相关论文
共 89 条
[71]  
VanderBeek EM, 1997, J COMP NEUROL, V384, P569, DOI 10.1002/(SICI)1096-9861(19970811)384:4<569::AID-CNE6>3.0.CO
[72]  
2-0
[73]   PREFERENTIAL INDUCTION OF C-FOS IMMUNOREACTIVITY IN VASOACTIVE INTESTINAL POLYPEPTIDE-INNERVATED GONADOTROPIN-RELEASING-HORMONE NEURONS DURING A STEROID-INDUCED LUTEINIZING-HORMONE SURGE IN THE FEMALE RAT [J].
VANDERBEEK, EM ;
VANOUDHEUSEN, HJC ;
BUIJS, RM ;
VANDERDONK, HA ;
VANDENHURK, R ;
WIEGANT, VM .
ENDOCRINOLOGY, 1994, 134 (06) :2636-2644
[74]  
VANDERBEEK EM, 1993, J NEUROENDOCRINOL, V5, P137
[75]   Evidence for Suprachiasmatic Vasopressin Neurones Innervating Kisspeptin Neurones in the Rostral Periventricular Area of the Mouse Brain: Regulation by Oestrogen [J].
Vida, B. ;
Deli, L. ;
Hrabovszky, E. ;
Kalamatianos, T. ;
Caraty, A. ;
Coen, C. W. ;
Liposits, Z. ;
Kallo, I. .
JOURNAL OF NEUROENDOCRINOLOGY, 2010, 22 (09) :1032-1039
[76]   VASOACTIVE INTESTINAL PEPTIDE - EVIDENCE FOR A HYPOTHALAMIC SITE OF ACTION TO RELEASE GROWTH-HORMONE, LUTEINIZING-HORMONE, AND PROLACTIN IN CONSCIOUS OVARIECTOMIZED RATS [J].
VIJAYAN, E ;
SAMSON, WK ;
SAID, SI ;
MCCANN, SM .
ENDOCRINOLOGY, 1979, 104 (01) :53-57
[77]   Projections From the Subparaventricular Zone Define Four Channels of Output From the Circadian Timing System [J].
Vujovic, Nina ;
Gooley, Joshua J. ;
Jhou, Thomas C. ;
Saper, Clifford B. .
JOURNAL OF COMPARATIVE NEUROLOGY, 2015, 523 (18) :2714-2737
[78]  
Wang O, 2012, THESIS
[79]   Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre [J].
Weaver, David R. ;
van der Vinne, Vincent ;
Giannaris, E. Lela ;
Vajtay, Thomas J. ;
Holloway, Kristopher L. ;
Anaclet, Christelle .
JOURNAL OF BIOLOGICAL RHYTHMS, 2018, 33 (02) :179-191
[80]   ROLE OF VIP IN THE REGULATION OF LH-SECRETION IN THE FEMALE RAT [J].
WEICK, RF ;
STOBIE, KM .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1995, 19 (02) :251-259