Changes in IGF-I, IGFBP-3 and ghrelin levels after adenotonsillectomy in children with sleep disordered breathing

被引：20

作者：

Guemuessoy, Murat ^{[1
]}

Atmaca, Sinan ^{[1
]}

Bilgici, Birsen ^{[2
]}

Uenal, Recep ^{[1
]}

机构：

[1] Ondokuz Mayis Univ, Sch Med, Dept Otolaryngol, Samsun, Turkey

[2] Ondokuz Mayis Univ, Sch Med, Dept Biochem, Samsun, Turkey

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2009年 / 73卷 / 12期

关键词：

IGF-I; IGFBP-3; Ghrelin; Adenotonsillar hypertrophy; Sleep disordered breathing; Adenotonsillectomy; GROWTH-FACTOR-I; APNEA SYNDROME; BIOCHEMICAL MARKERS; HORMONE-SECRETION; OBESE CHILDREN; FOOD-INTAKE; INSULIN; HYPERTROPHY; ADOLESCENTS; REDUCTION;

D O I：

10.1016/j.ijporl.2009.08.025

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objective: The aim of this study was to determine the changes in insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and ghrelin levels following adenotonsillectomy (T&A) in children with sleep disordered breathing (SDB). Methods: Forty children (mean age 4.85 +/- 2.15 years) clinically diagnosed with adenotonsillar hypertrophy (ATH) related SDB were enrolled. All children underwent T&A. Serum levels of IGF-I, IGFBP-3 and ghrelin were measured before and 6 months after T&A. Results: Serum levels of IGF-I and IGFBP-3 were significantly higher after T&A (p < 0.001). Serum ghrelin levels showed a significant decrease after T&A (p < 0.001). Conclusion: Children with ATH related SDB who underwent T&A showed significant increases in IGF-I and IGFBP-3 levels indicating an increase in diurnal growth hormone secretion as well as a significant decrese in ghrelin levels indicating an increased oral food intake in the postoperative period. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1653 / 1656

页数：4

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