The state of the union: the cell biology of fertilization

被引：103
作者：
Evans, JP [1 ]
Florman, HM
机构：
[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Div Reprod Biol, Baltimore, MD 21205 USA
[2] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA
来源：
NATURE CELL BIOLOGY | 2002年 / 4卷
关键词：
D O I：
10.1038/ncb-nm-fertilityS57
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Fertilization is the process by which sperm and egg unite. An expanded understanding of the mechanisms that underlie these events has provided insights into an important aspect of early development and also has proven to be a valuable model in which to study cellular function. In addition, many emerging strategies for contraception and for the treatment of infertility are based on the mechanism of gamete interaction. Here, we discuss the cell and molecular biology of mammalian fertilization, highlight selected recent breakthroughs and attempt to identify key unanswered questions.
引用
收藏
页码：S57 / S63
页数：7
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