Monoterpenes from Paeonia albiflora and Their Inhibitory Activity on Nitric Oxide Production by Lipopolysaccharide-Activated Microglia

被引：61

作者：

Duan, Wen-Juan ^{[1
]}

Yang, Jing-Yu ^{[2
]}

Chen, Li-Xia ^{[1
]}

Zhang, Li-Jia ^{[2
]}

Jiang, Zhi-Hu ^{[2
]}

Cai, Xu-Dong ^{[2
]}

Zhang, Xue ^{[1
]}

Qiu, Feng ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 09期

关键词：

GLYCOSIDE; PAEONIFLORIN; SUFFRUTICOSA; LACTIFLORA; CELLS; PEONY; RADIX;

D O I：

10.1021/np9001898

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eleven new monoterpenes, paeonidangenin (1), paeonidanin A (2), paeonidanin B (3), paeonidanin C (4), paeonidanin D (5), paeonidanin E (6), paeoniflorone (7), 4-O-methylbenzoylpaeoniflorin (8), 4-O-methylgalloylpaeoniflorin (9), 4-O-methyldebenzoylpaeoniflorin (10), and 4-O-methylalbiflorin (11), were isolated from the 60% ethanol extract of the roots of Paeonia albiflora. Their structures were determined primarily on the basis of 1D and 2D NMR techniques and MS studies. Paeonidanins D (5) and E (6) are unprecedented examples of "cage-like" monoterpene dimers. The inhibitory effects of the isolated compounds on nitric oxide production by lipopolysaccharide (LPS)-activated N9 microglia were evaluated.

引用

页码：1579 / 1584

页数：6

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