Total syntheses of O-4,O-9-dimethyl stealthins A and C

被引:33
作者
Koyama, H [1 ]
Kamikawa, T [1 ]
机构
[1] KINKI UNIV,DEPT CHEM,FAC SCI & TECHNOL,HIGASHIOSAKA,OSAKA 577,JAPAN
关键词
D O I
10.1016/S0040-4039(97)00793-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
O-4,O-9-Dimethylstealthin A (11-amino-5-hydroxy-2-hydroxymethyl-4,9-dimethoxy-benzo[b]fluoren-10-one) and O-4,O-9-dimethylstealthin C (11-amino-5-hydroxy-4,9-dimethoxy-2-methyl-benzo[b]fluoren-10-one), methylated derivatives of radical scavengers produced by Stereptomyces viridochromogenes, were synthesized using the Suzuki coupling reaction as a key step. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:3973 / 3976
页数:4
相关论文
共 8 条
[1]   ORTHO METALATION DIRECTED BY ALPHA-AMINO ALKOXIDES [J].
COMINS, DL ;
BROWN, JD .
JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (06) :1078-1083
[2]   SYNTHESIS OF PUTATIVE INTERMEDIATES IN THE BIOSYNTHESIS OF THE KINAMYCIN ANTIBIOTICS - TOTAL SYNTHESIS OF PHENANTHROVIRIDIN AGLYCON AND RELATED-COMPOUNDS [J].
GORE, MP ;
GOULD, SJ ;
WELLER, DD .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (10) :2774-2783
[3]   Identification of prekinamycin in extracts of Streptomyces murayamaensis [J].
Gould, SJ ;
Chen, J ;
Cone, MC ;
Gore, MP ;
Melville, CR ;
Tamayo, N .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (17) :5720-5721
[4]   Kinamycin biosynthesis. Synthesis, isolation, and incorporation of stealthin C, an aminobenzo[b]fluorene [J].
Gould, SJ ;
Melville, CR ;
Cone, MC ;
Chen, J ;
Carney, JR .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (02) :320-324
[5]  
GRUNWELL JR, 1980, TETRAHEDRON LETT, V21, P4305
[6]  
HASS HB, 1963, ORG SYNTH, V4, P932
[7]  
IIHAMA T, 1989, SYNTHESIS-STUTTGART, P184
[8]   STRUCTURES OF STEALTHINS-A AND STEALTHINS-B, NEW FREE-RADICAL SCAVENGERS OF MICROBIAL ORIGIN [J].
SHINYA, K ;
FURIHATA, K ;
TESHIMA, Y ;
HAYAKAWA, Y ;
SETO, H .
TETRAHEDRON LETTERS, 1992, 33 (46) :7025-7028