Peripheral Artery Disease in Diabetes Mellitus: Focus on Novel Treatment Options

被引：5

作者：

Demarchi, Andrea ^{[1
]}

Somaschini, Alberto ^{[2
,3
]}

Cornara, Stefano ^{[3
]}

Androulakis, Emmanuel ^{[2
]}

机构：

[1] Cardioctr Ticino, Lugano, Switzerland

[2] Royal Brompton & Harefield NHS Fdn Trust, Adult Intens Care Unit, London, England

[3] San Paolo Hosp, Dept Cardiol, Savona, Italy

来源：

CURRENT PHARMACEUTICAL DESIGN | 2020年 / 26卷 / 46期

关键词：

Diabetes mellitus; peripheral artery disease; novel treatments; pro-coagulative unbalance; pleiotropic; endothelial dysfunction; NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; ENDOTHELIAL PROGENITOR CELLS; COTRANSPORTER; INHIBITION; ANKLE-BRACHIAL INDEX; MYOCARDIAL-INFARCTION; CARDIOVASCULAR OUTCOMES; OXIDATIVE STRESS; INTERMITTENT CLAUDICATION; VASCULAR ENDOTHELIUM;

D O I：

10.2174/1389201021666201126143217

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetes mellitus (DM) and peripheral artery disease (PAD) are two clinical entities closely associated. They share many pathophysiological pathways such as inflammation, endothelial dysfunction, oxidative stress and pro-coagulative unbalance. Emerging data focusing on agents targeting these pathways may be promising. Moreover, due to the increased cardiovascular risk, there is a growing interest in cardiovascular and "pleiotropic" effects of novel glucose lowering drugs. This review summarizes the main clinical features of PAD in patients, the diagnostic process and current medical/interventional approaches, ranging from "classical treatment" to novel agents.

引用

页码：5953 / 5968

页数：16

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