Vulvovaginal Atrophy

被引:346
作者
Mac Bride, Maire B. [1 ]
Rhodes, Deborah J. [2 ]
Shuster, Lynne T. [1 ]
机构
[1] Mayo Clin, Div Gen Internal Med, Rochester, MN 55905 USA
[2] Mayo Clin, Div Prevent Occupat & Aerosp Med, Rochester, MN 55905 USA
关键词
LOW-DOSE ESTRADIOL; QUALITY-OF-LIFE; PLACEBO-CONTROLLED TRIAL; POSTMENOPAUSAL WOMEN; BREAST-CANCER; INTRAVAGINAL ESTRIOL; ESTROGEN; TAMOXIFEN; SYMPTOMS; ENDOMETRIAL;
D O I
10.4065/mcp.2009.0413
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vulvovaginal atrophy (VVA) is a common and underreported condition associated with decreased estrogenization of the vaginal tissue. Symptoms Include dryness, Irritation, soreness, and dyspareunia with urinary frequency, urgency, and urge Incontinence. It can occur at any time In a woman's life cycle, although more commonly In the postmenopausal phase, during which the prevalence Is close to 50%. Clinical findings Include the presence of pale and dry vulvovaginal mucosa with petechiae. Vaginal rugae disappear, and the cervix may become flush with the vaginal wall. A vaginal pH of 4.6 or more supports the diagnosis of VVA. Even while taking systemic estrogen, 10% to 20% of women may still have residual VVA symptoms. Breast cancer treatment Increases the prevalence of VVA because the surgical, endocrine, and chemotherapeutic agents used In its treatment can cause or exacerbate VVA. Local estrogen treatment for this group of women remains controversial.
引用
收藏
页码:87 / 94
页数:8
相关论文
共 51 条
[1]  
[Anonymous], 1991, ANN NY ACAD SCI
[2]   Efficacy of low-dose estradiol vaginal tablets in the treatment of atrophic vaginitis - A randomized controlled trial [J].
Bachmann, Gloria ;
Lobo, Rogerio A. ;
Gut, Robert ;
Nachtigall, Lila ;
Notelovitz, Morris .
OBSTETRICS AND GYNECOLOGY, 2008, 111 (01) :67-76
[3]   The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society [J].
Bachmann, Gloria A. ;
Johnston, Shawna L. ;
Kessel, Bruce ;
Knobf, M. Tish ;
Stewart, Elizabeth G. .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2007, 14 (03) :357-371
[4]   Urogenital ageing and its effect on sexual health in older British women [J].
Barlow, DH ;
Cardozo, LD ;
Francis, RM ;
Griffin, M ;
Hart, DM ;
Stephens, E ;
Sturdee, DW .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1997, 104 (01) :87-91
[5]  
BROWN KH, 1987, OBSTET GYN CLIN N AM, V14, P13
[6]   Quality of life of postmenopausal women in the ATAC ("Arimidex", tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for early breast cancer [J].
Cella, David ;
Fallowfield, Lesley ;
Barker, Peter ;
Cuzick, Jack ;
Locker, Gershon ;
Howell, Anthony .
BREAST CANCER RESEARCH AND TREATMENT, 2006, 100 (03) :273-284
[7]   Association of breast cancer and its therapy with menopause-related symptoms [J].
Crandall, C ;
Petersen, L ;
Ganz, PA ;
Greendale, GA .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2004, 11 (05) :519-530
[8]   Adverse events reported by postmenopausal women in controlled trials with raloxifene [J].
Davies, GC ;
Huster, WJ ;
Lu, YL ;
Plouffe, L ;
Lakshmanan, M .
OBSTETRICS AND GYNECOLOGY, 1999, 93 (04) :558-565
[9]   A prospective population-based study of menopausal symptoms [J].
Dennerstein, L ;
Dudley, EC ;
Hopper, JL ;
Guthrie, JR ;
Burger, HG .
OBSTETRICS AND GYNECOLOGY, 2000, 96 (03) :351-358
[10]   Efficacy of low-dose intravaginal estriol on urogenital aging in postmenopausal women [J].
Dessole, S ;
Rubattu, G ;
Ambrosini, G ;
Gallo, O ;
Capobianco, G ;
Cherchi, PL ;
Marci, R ;
Cosmi, E .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2004, 11 (01) :49-56