Association of NTCP Gene Polymorphisms and Spontaneous Clearance of Hepatitis B Virus in Asia: A Meta-Analysis

被引：3
作者：
Hu, Peipei [1 ]
Liu, Jundi [1 ]
Zhang, Dingmei [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou, Guangdong, Peoples R China
来源：
HEPATITIS MONTHLY | 2019年 / 19卷 / 09期
关键词：
Hepatitis B Virus; Single Nucleotide Polymorphism; Sodium-Bile Acid Cotransporter; TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; INFECTION; SLC10A1; VARIANTS; MARKERS;
D O I：
10.5812/hepatmon.94500
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Context: It is reported that NTCP(sodium taurocholate cotransporting polypeptide) gene polymorphisms are associated with spontaneous clearance of hepatitis B virus (HBV), but the results are contradictory. Therefore, the current meta-analysis aimed at systematically clarifying the association between NTCP gene polymorphisms and spontaneous clearance of HBV in Asia. Evidence Acquisition: PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure and China Wanfang Data were searched systematically for articles published before 09 August 2019. Results: A total of nine case-control studies were finally included in the current meta-analysis. The pooled results indicated that the NTCP gene rs2296651 A allele is a protective factor for spontaneous clearance of HBV (GG vs. GA+AA: odds ratio (OR) = 0.73, 95% confidence interval (CI) = 0.58 - 0.93; GG vs. GA:OR = 0.74, 95% CI = 0.59 - 0.93; G vs. A allele: OR = 0.74, 95%CI = 0.58 - 0.94). Conclusions: NTCP gene rs2296651 polymorphism is correlated with spontaneous clearance of HBV, while NTCP gene rs4646287 and rs7154439 variants are not associated with persistent HBV susceptibility.
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