Molecular descriptors of N-arylhydroxamic acids:: A tool in drug design

被引：9

作者：

Tiwari, Vaishali ^{[1
]}

Pande, Rama ^{[1
]}

机构：

[1] Pt Ravishankar Shukla Univ, Raipur 492010, Chhattisgarh, India

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2006年 / 68卷 / 04期

关键词：

drug design; hydrogen bond; hydroxamic acids; log P; molecular descriptors; steric descriptor;

D O I：

10.1111/j.1747-0285.2006.00433.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The partition coefficient in the 1-octanol/water system, log P(O/W), is a measure of lipophilicity. It is used as a predictor of solute-membrane partitioning. The objective of this study was to measure the log P(O/W) of five hydroxamic acids. Other molecular descriptors of these solutes, namely molar volume, molar refraction, parachor, polarizability (pi*), hydrogen-bond donor acidity (epsilon alpha) and hydrogen-bond acceptor basicity (epsilon beta), have also been discussed. These properties represent the combined effects of a number of intermolecular forces between a solute and its environment.

引用

页码：225 / 228

页数：4

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