'Off-the-shelf' immunotherapy with iPSC-derived rejuvenated cytotoxic T lymphocytes

被引：19

作者：

Ando, Miki ^{[1
,2
]}

Nakauchi, Hiromitsu ^{[1
,3
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Div Stem Cell Therapy, Ctr Stem Cell Biol & Regenerative Med, Tokyo, Japan

[2] Juntendo Univ Sch Med, Dept Transfus Med & Stem Cell Regulat, Tokyo, Japan

[3] Stanford Univ Sch Med, Inst Stem Cell Biol & Regenerative Med, Stanford, CA 94301 USA

来源：

EXPERIMENTAL HEMATOLOGY | 2017年 / 47卷

关键词：

PLURIPOTENT STEM-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; RECEPTOR GENE-THERAPY; ADOPTIVE IMMUNOTHERAPY; IN-VIVO; METASTATIC MELANOMA; CANCER REGRESSION; GRANZYME-B; INDOLEAMINE 2,3-DIOXYGENASE; HEMATOPOIETIC PROGENITORS;

D O I：

10.1016/j.exphem.2016.10.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adoptive T-cell therapy to target and kill tumor cells shows promise and induces durable remissions in selected malignancies. However, for most cancers, clinical utility is limited. Cytotoxic T lymphocytes continuously exposed to viral or tumor antigens, with long-term expansion, may become unable to proliferate ("exhausted"). To exploit fully rejuvenated induced pluripotent stem cell (iPSC)-derived antigen-specific cytotoxic T lymphocytes is a potentially powerful approach. We review recent progress in engineering iPSC-derived T cells and prospects for clinical translation. We also describe the importance of introducing a suicide gene safeguard system into adoptive T-cell therapy, including iPSC-derived T-cell therapy, to protect from unexpected events in first-in-humans clinical trials. (C) 2016 ISEH- International Society for Experimental Hematology. Published by Elsevier Inc.

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页码：2 / 12

页数：11

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