Microwave-assisted synthesis of bipyrazolyls and pyrazolyl-substituted pyrimidines

被引：14

作者：

de la Hoz, Antonio ^{[1
]}

Diaz, Angel

Elguero, Jose

Jimenez, Agustin

Moreno, Andres

Ruiz, Amparo

Sanchez-Migallon, Ana

机构：

[1] Univ Castilla La Mancha, Fac Quim, E-13071 Ciudad Real, Spain

[2] CSIC, Inst Quim Med, E-28006 Madrid, Spain

来源：

TETRAHEDRON | 2007年 / 63卷 / 03期

关键词：

D O I：

10.1016/j.tet.2006.10.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the preparation of 1,4'-bipyrazolyls and 4-pyrazolylpyrimidines by the reaction of 2-pyrazolyl-3-dimethylamino acrylate and acrylonitrile with double nucleophilic reagents such as hydrazines, urea and guanidine. Reactions were performed under microwave irradiation in 5-60 min. This is a useful procedure for the preparation of valuable compounds with applications in medicinal and coordination chemistry. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：748 / 753

页数：6

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