DNA methylation as a genomic marker of exposure to chemical and environmental agents

被引：49

作者：

Meehan, Richard R. ^{[1
]}

Thomson, John P. ^{[1
]}

Lentini, Antonio ^{[2
]}

Nestor, Coim E. ^{[2
]}

Pennings, Sari ^{[3
]}

机构：

[1] Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Linkoping Univ, Dept Clin & Expt Med, SE-58183 Linkoping, Sweden

[3] Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2018年 / 45卷

基金：

瑞典研究理事会; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

ENDOCRINE DISRUPTORS; MOUSE-LIVER; 5-HYDROXYMETHYLCYTOSINE; HYPERMETHYLATION; DEMETHYLATION; PROMOTER; GENE; VINCLOZOLIN; EXPRESSION; SIGNATURES;

D O I：

10.1016/j.cbpa.2018.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

引用

页码：48 / 56

页数：9

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