Cornus sanguinea Fruits: a Source of Antioxidant and Antisenescence Compounds Acting on Aged Human Dermal and Gingival Fibroblasts *

被引：8

作者：

Iannuzzi, Anna Maria ^{[1
]}

Giacomelli, Chiara ^{[1
,2
,3
]}

De Leo, Marinella ^{[1
,2
,3
]}

Russo, Lara ^{[1
]}

Camangi, Fabiano ^{[4
]}

De Tommasi, Nunziatina ^{[5
]}

Braca, Alessandra ^{[1
,2
,3
]}

Martini, Claudia ^{[1
,2
,3
]}

Trincavelli, Maria Letizia ^{[1
,2
,3
]}

机构：

[1] Univ Pisa, Dipartimento Farm, Via Bonanno 33, I-56126 Pisa, Italy

[2] Univ Pisa, Ctr Interdipartimentale Ric Nutraceut & Alimentaz, Pisa, Italy

[3] CISUP, Ctr Instrumentat Sharing, Pisa, Italy

[4] Scuola Super Sant Anna, Pisa, Italy

[5] Univ Salerno, Dipartimento Farm, Fisciano, SA, Italy

来源：

PLANTA MEDICA | 2021年 / 87卷 / 10/11期

关键词：

Cornus sanguinea; Cornaceae; cyclohexylethanoids; flavonol  glycosides; antioxidant; human fibroblasts; CYCLOHEXYL-ETHANOL DERIVATIVES; STRUCTURE ELUCIDATION; GLUCOSIDES; SENESCENCE; COLLAGEN; STRESS; MATRIX; CELLS;

D O I：

10.1055/a-1471-6666

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new compounds, a flavonol glycoside ( 1 ), a megastigmane ( 2 ), 2 cyclohexylethanoids ( 3, 4 ), and a phenylethanoid derivative ( 5 ), together with 15 known compounds ( 6 - 20 ) including flavonoid glycosides, cyclohexylethanoids, and phenolic compounds, have been isolated from Cornus sanguinea drupes. All the structures have been determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry data. The antioxidant capability of the most representative isolated compounds was evaluated in the hydrogen peroxide (H (2) O (2) )-induced premature cellular senescence model of human dermal and gingival fibroblasts. Several derivatives counteracted the increase of reactive oxigen species (ROS) production in both cellular models. Among the most promising, compounds 8, 14 , and 20 were able to counteract cell senescence, decreasing the expression of p21 and p53. Furthermore, compound 14 decreased the expression of inflammatory cytokines (IL-6) in both cell models and counteracted the decrease of collagen expression induced by the H (2) O (2) in dermal human fibroblasts. These data highlight the anti-aging properties of several isolated compounds from C. sanguinea drupes, supporting its possible use in the cure of skin or periodontitis lesions.

引用

页码：879 / 891

页数：13