Heparin-Coated Gold Nanoparticles for Liver-Specific CT Imaging

被引：131

作者：

Sun, In-Cheol ^{[1
]}

Eun, Dae-Kyung ^{[2
]}

Na, Jin Hee ^{[1
]}

Lee, Seulki ^{[1
]}

Kim, Il-Jin ^{[3
]}

Youn, In-Chan ^{[1
]}

Ko, Chang-Yong ^{[4
]}

Kim, Han-Sung ^{[4
]}

Lim, Dohyung ^{[5
]}

Choi, Kuiwon ^{[1
]}

Messersmith, Phillip B. ^{[6
]}

Park, Tae Gwan ^{[7
]}

Kim, Sang Yoon ^{[8
]}

Kwon, Ick Chan ^{[1
]}

Kim, Kwangmeyung ^{[1
]}

Ahn, Cheol-Hee ^{[2
]}

机构：

[1] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul 136791, South Korea

[2] Seoul Natl Univ, Dept Mat Sci & Engn, Seoul 151744, South Korea

[3] Korea Univ, Dept Chem, Coll Sci, Seoul 136791, South Korea

[4] Yonsei Univ, Dept Biomed Engn, Wonju 220710, Ganwondo, South Korea

[5] Korea Inst Ind Technol, Silver Technol Ctr, Cheonan, Chungnam, South Korea

[6] Northwestern Univ, Evanston, IL 60208 USA

[7] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[8] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol Head & Neck Surg, Seoul 138736, South Korea

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2009年 / 15卷 / 48期

关键词：

computed tomography; gold; heparin; imaging agents; nanoparticles; RAY COMPUTED-TOMOGRAPHY; CONTRAST AGENT; DEOXYCHOLIC-ACID; COLLOIDAL GOLD; BLOOD; METASTASES; STABILITY; ANCHOR;

D O I：

10.1002/chem.200902344

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

"Chemical Equation Presented" Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：13341 / 13347

页数：7

共 37 条

[1]

ACKERMAN NB, 1969, SURGERY, V66, P1067

[2] Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging [J].

Alric, Christophe ;

Taleb, Jacqueline ;

Le Duc, Geraldine ;

Mandon, Celine ;

Billotey, Claire ;

Le Meur-Herland, Alice ;

Brochard, Thierry ;

Vocanson, Francis ;

Janier, Marc ;

Perriat, Pascal ;

Roux, Stephane ;

Tillement, Olivier .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (18) :5908-5915

[3] Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery [J].

Bergen, Jamie M. ;

Von Recum, Horst A. ;

Goodman, Thomas T. ;

Massey, Archna P. ;

Pun, Suzie H. .

MACROMOLECULAR BIOSCIENCE, 2006, 6 (07) :506-516

[4] Colloidal gold nanoparticles as a blood-pool contrast agent for x-ray computed tomography in mice [J].

Cai, Quan-Yu ;

Kim, Sun Hee ;

Choi, Kyu Sil ;

Kim, Soo Yeon ;

Byun, Seung Jae ;

Kim, Kyoung Woo ;

Park, Seong Hoon ;

Juhng, Seon Kwan ;

Yoon, Kwon-Ha .

INVESTIGATIVE RADIOLOGY, 2007, 42 (12) :797-806

[5] Gold nanocages: Bioconjugation and their potential use as optical imaging contrast agents [J].

Chen, J ;

Saeki, F ;

Wiley, BJ ;

Cang, H ;

Cobb, MJ ;

Li, ZY ;

Au, L ;

Zhang, H ;

Kimmey, MB ;

Li, XD ;

Xia, YN .

NANO LETTERS, 2005, 5 (03) :473-477

[6] Mussel adhesive protein mimetic polymers for the preparation of nonfouling surfaces [J].

Dalsin, JL ;

Hu, BH ;

Lee, BP ;

Messersmith, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (14) :4253-4258

[7] GLYCOSAMINOGLYCANS IN RAT MUCOSAL MAST-CELLS [J].

ENERBACK, L ;

KOLSET, SO ;

KUSCHE, M ;

HJERPE, A ;

LINDAHL, U .

BIOCHEMICAL JOURNAL, 1985, 227 (02) :661-668

[8] Gold nanoparticles: a new X-ray contrast agent [J].

Hainfeld, JF ;

Slatkin, DN ;

Focella, TM ;

Smilowitz, HM .

BRITISH JOURNAL OF RADIOLOGY, 2006, 79 (939) :248-253

[9] THE UPTAKE OF HEPARIN BY LIVER SINUSOIDAL CELLS IN NORMAL AND ATHEROSCLEROTIC RABBITS [J].

HIEBERT, L .

THROMBOSIS RESEARCH, 1981, 21 (4-5) :383-390

[10] Formulation and stability of surface-tethered DNA-gold-dendron nanoparticles [J].

Hussain, N ;

Singh, B ;

Sakthivel, T ;

Florence, AT .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 254 (01) :27-31

← 1 2 3 4 →