Inherited susceptibility to pediatric acute lymphoblastic leukemia

被引：8
作者：
Levine, Ross L. [1 ,2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Pathogenesis Program, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Leukemia Serv, Dept Med, New York, NY 10021 USA
来源：
NATURE GENETICS | 2009年 / 41卷 / 09期
关键词：
CANCER; DELETION; RISKS; TWINS;
D O I：
10.1038/ng0909-957
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Although genome-wide analyses have identified somatic alterations contributing to the pathogenesis of pediatric acute lymphoblastic leukemia (ALL), few studies have identified germline variants conferring risk of this disease. Two reports now provide the first genome-wide glimpse into the role of inherited alleles in ALL pathogenesis.
引用
收藏
页码：957 / 958
页数：2
相关论文
共 12 条
  • [1] Somatic and germline genetics at the JAK2 locus
    Campbell, Peter J.
    [J]. NATURE GENETICS, 2009, 41 (04) : 385 - 386
  • [2] INUTERO REARRANGEMENTS IN THE TRITHORAX-RELATED ONCOGENE IN INFANT LEUKEMIAS
    FORD, AM
    RIDGE, SA
    CABRERA, ME
    MAHMOUD, H
    STEEL, CM
    CHAN, LC
    GREAVES, M
    [J]. NATURE, 1993, 363 (6427) : 358 - 360
  • [3] Risks of leukaemia and solid tumours in individuals with Down's syndrome
    Hasle, H
    Clemmensen, IH
    Mikkelsen, M
    [J]. LANCET, 2000, 355 (9199) : 165 - 169
  • [4] Risks among siblings and twins for childhood acute lymphoid leukaemia: results from the Swedish Family-Cancer Database
    Hemminki, K
    Jiang, Y
    [J]. LEUKEMIA, 2002, 16 (02) : 297 - 298
  • [5] Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
    Laken, SJ
    Petersen, GM
    Gruber, SB
    Oddoux, C
    Ostrer, H
    Giardiello, FM
    Hamilton, SR
    Hampel, H
    Markowitz, A
    Klimstra, D
    Jhanwar, S
    Winawer, S
    Offit, K
    Luce, MC
    Kinzler, KW
    Vogelstein, B
    [J]. NATURE GENETICS, 1997, 17 (01) : 79 - 83
  • [6] Environmental and heritable factors in the causation of cancer - Analyses of cohorts of twins from Sweden, Denmark, and Finland.
    Lichtenstein, P
    Holm, NV
    Verkasalo, PK
    Iliadou, A
    Kaprio, J
    Koskenvuo, M
    Pukkala, E
    Skytthe, A
    Hemminki, K
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (02) : 78 - 85
  • [7] MORRELL D, 1986, JNCI-J NATL CANCER I, V77, P89
  • [8] BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    Mullighan, Charles G.
    Miller, Christopher B.
    Radtke, Ina
    Phillips, Letha A.
    Dalton, James
    Ma, Jing
    White, Deborah
    Hughes, Timothy P.
    Le Beau, Michelle M.
    Pui, Ching-Hon
    Relling, Mary V.
    Shurtleff, Sheila A.
    Downing, James R.
    [J]. NATURE, 2008, 453 (7191) : 110 - +
  • [9] Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
    Mullighan, Charles G.
    Goorha, Salil
    Radtke, Ina
    Miller, Christopher B.
    Coustan-Smith, Elaine
    Dalton, James D.
    Girtman, Kevin
    Mathew, Susan
    Ma, Jing
    Pounds, Stanley B.
    Su, Xiaoping
    Pui, Ching-Hon
    Relling, Mary V.
    Evans, William E.
    Shurtleff, Sheila A.
    Downing, James R.
    [J]. NATURE, 2007, 446 (7137) : 758 - 764
  • [10] Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia.
    Mullighan, Charles G.
    Su, Xiaoping
    Zhang, Jinghui
    Radtke, Ina
    Phillips, Letha A. A.
    Miller, Christopher B.
    Ma, Jing
    Liu, Wei
    Cheng, Cheng
    Schulman, Brenda A.
    Harvey, Richard C.
    Chen, I-Ming
    Clifford, Robert J.
    Carroll, William L.
    Reaman, Gregory
    Bowman, W. Paul
    Devidas, Meenakshi
    Gerhard, Daniela S.
    Yang, Wenjian
    Relling, Mary V.
    Shurtleff, Sheila A.
    Campana, Dario
    Borowitz, Michael J.
    Pui, Ching-Hon
    Smith, Malcolm
    Hunger, Stephen P.
    Willman, Cheryl L.
    Downing, James R.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (05) : 470 - 480
12