共 171 条
Mechanisms of Polycomb gene silencing: knowns and unknowns
被引:1083
作者:

Simon, Jeffrey A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

Kingston, Robert E.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA
机构:
[1] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA
[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
关键词:
RNA-POLYMERASE-II;
HISTONE METHYLTRANSFERASE ACTIVITY;
EMBRYONIC STEM-CELLS;
POLYCOMB/TRITHORAX RESPONSE ELEMENTS;
TRITHORAX GROUP PROTEINS;
DROSOPHILA-MELANOGASTER;
BITHORAX COMPLEX;
HOMEOTIC GENE;
H2A UBIQUITINATION;
STRUCTURAL BASIS;
D O I:
10.1038/nrm2763
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Polycomb proteins form chromatin-modifying complexes that implement transcriptional silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins, including dozens of genes that encode crucial developmental regulators in organisms ranging from plants to humans. Two main families of complexes, called Polycomb repressive complex 1 (PRC1) and PRC2, are targeted to repressed regions. Recent studies have advanced our understanding of these complexes, including their potential mechanisms of gene silencing, the roles of chromatin modifications, their means of delivery to target genes and the functional distinctions among variant complexes. Emerging concepts include the existence of a Polycomb barrier to transcription elongation and the involvement of non-coding RNAs in the targeting of Polycomb complexes. These findings have an impact on the epigenetic programming of gene expression in many biological systems.
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页码:697 / 708
页数:12
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